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. Author manuscript; available in PMC: 2016 Nov 18.
Published in final edited form as: Nature. 2016 May 18;534(7606):272–276. doi: 10.1038/nature17963

Extended Data Table 1. mTOR mutations found in human patient samples.

List of some FRB and Kinase Domain mTOR mutations found in human patient samples. Data was collected from the cBio-portal, MSKCC.

References Histology mTOR mutations Domains Treatments
TCGA-B0-4852-01 ccRCC (TCGA) E2033V FRB Baseline
Wagle et al. 2014 Thyroid F2108L FRB Everolimus
TCGA-DU-6393-01 Glioma (TCGA) M2327I Kinase Baseline
TCGA-A3-3347-01 ccRCC (TCGA) M2327I Kinase Baseline
P-00006559-T01-IM5 Colorectal Cancer
(MSKCC-IMPACT)		 M2327I Kinase Baseline
P-0000645-T01-IM3 Bladder Urothelial
Carcinoma
(MSKCC-IMPACT)		 M2327I Kinase Baseline
ccRCC_28 ccRCC (U Tokyo) M2327I Kinase Baseline
P-0000614-T01-IM3 Endometrial Cancer
(MSKCC-IMPACT)		 M2327I Kinase Baseline