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. Author manuscript; available in PMC: 2016 Jun 10.
Published in final edited form as: J Med Chem. 2015 Aug 4;58(15):5863–5888. doi: 10.1021/acs.jmedchem.5b00423

Scheme 5a.

Scheme 5a

aReagents and conditions: (a) TFA, CH2Cl2, rt, 3 h; (b) H2 (50 psi), 10% Pd/C, CH3OH, rt, 6 h; (c) (i) 2-chloro-6-methylpyrimidine-4-carboxylic acid, Et3N, DMF, 60 °C, 16 h; (ii) 2 N aq NaOH, THF, CH3OH, rt, 16 h; (iii) 2 N aq HCl.