Scheme 7a.
aReagents and conditions: (a) (i) 2-chloro-6-methylpyrimidine-4-carbonitrile, i-Pr2NEt, DMF, 60 °C, 16 h; (b) LiOH·H2O, THF, H2O, 70 °C, 18 h; (c) NaN3, NH4Cl, DMF, 130 °C (microwave irradiation), 1 h.
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