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aReagents and conditions: (a) (i) substituted phenyl or pyridyl boronic acid, Pd(PPh3)4, 2.0 M Na2CO3, DME, 80 °C, 6 h; (b) H2 (40 psi), 10% Pd/C, CH3OH, rt, 16 h; (c) 2.0 M HCl in Et2O, CH2Cl2, 0 °C to rt, 24 h; (d) (i) methyl 2-chloro-6-methylpyrimidine-4-carboxylate, Et3N, DMF, 60 °C, 16 h; (ii) 2 N aq NaOH, THF, CH3OH, rt, 16 h; (iii) 2 N aq HCl.
