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(A) Plasma RBP4 levels (µg/mL) in male Sprague–Dawley rats following single (Day 1, Group 1) and 7-day (Day 7, Group 3) 18.2 µmol/kg (5 mg/kg) QD dose administration of analogue 33. Data represented as the mean (SD). (B) Plasma RBP4 levels (µg/mL) at predose time-points during the 7-day 5 mg/kg QD oral dose administration of analogue 33 (Group 3) or test article vehicle (Group 2) in Sprague–Dawley rats. Data represented as the mean (SD).
