Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
aReagents and conditions: (a) tert-butyl piperazine-1-carboxylate, Pd(OAc)2, BINAP, NaOt-Bu toluene, 110 °C, 16 h; (b) 2.0 M HCl solution in Et2O, CH2Cl2, rt, 3 h; (c) methyl 2-chloro-6-methylpyrimidine-4-carboxylate, i-Pr2NEt, DMF, 60 °C, 16 h; (d) (i) LiOH·H2O, H2O, THF, rt, 16 h; (ii) 2 N aq HCl.
