Fig 5. Venn diagrams showing the overlap of the proteins that undergo post-translational modifications multiple times (mPTM) [27], and the multiple-localized hub proteins.

The mPTM proteins were obtained from Supplementary File 2 of [27]. We regarded mPTM proteins as proteins that undergo PTM more than once (exactly speaking, the classification group symbol in the File is at least 2), and did not decompose further classifications. Proteins with PTM that were not annotated in the File were disregarded. A. Detailed classification. The small circles in NCP and CMP are the proteins with PTM* × Transcription* (TC*) and those with PTM’ + Nucleotide-binding (Nb), respectively. B. Schematic classification.