Table 1. Hub proteins localized in both the nucleus and cytoplasm, annotated by PTM* and transcription* (more than 100 PPIs).
| protein | Uniprot | HPRD | PPI | keyword | length | %ID | LID | domains | function | process | TL | IDEAL | ProS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Histone acetyltransferase p300 | Q09472 | 4078 | 209 | P/Ac/U/T | 2414 | 57 | 319 | 8 | TcoA | TC | 70 | ||
| CREB-binding protein (CBP) | Q92793 | 2534 | 198 | P/Ac/U/T/Av | 2442 | 61 | 340 | 8 | TcoA | TC | 92 | x | |
| Mothers against decapentaplegic homolog 3 (Smad3) | P84022 | 4380 | 182 | P/Ac/U/T/D | 425 | 16 | 57 | 2 | TF | Smad | P | 113 | x |
| Mothers against decapentaplegic homolog 2 (Smad2) | Q15796 | 3221 | 165 | P/Ac/U/T/D | 467 | 14 | 60 | 2 | TF | Smad | P | 127 | x |
| Mitogen-activated protein kinase 1 (MAPK1) | P28482 | 1496 | 160 | P/Ac/U/T/D/R | 360 | 4 | 11 | 1 | PK | MAPK | P | ||
| Ataxin-1 | P54253 | 3333 | 159 | P/U/T/D/R | 815 | 42 | 118 | 3 | CB | Notch | |||
| Mothers against decapentaplegic homolog 4 (Smad4) | Q13485 | 2995 | 150 | P/Ac/U/T/D | 552 | 31 | 164 | 2 | TF | Smad | P | 132 | |
| Androgen receptor (AR) | P10275 | 2437 | 150 | P/U/T/D/Av | 919 | 60 | 554 | 4 | NR/TF | NR | L | 20 | |
| Coiled-coil domain-containing protein 85B (Ccdc85B) | Q15834 | 16101 | 129 | Ac/T/R | 202 | 40 | 51 | 1 | TcoR | ||||
| Transcription factor p65 | Q04206 | 1241 | 113 | P/Ac/U/T/D/Av | 551 | 45 | 231 | 1 | TF | NF-κΒ | P | 207 | x |
| Mothers against decapentaplegic homolog 9 (Smad9) | O15198 | 4484 | 110 | P/T/D | 467 | 24 | 102 | 2 | TF | Smad | P | ||
| Mothers against decapentaplegic homolog 1 (Smad1) | Q15797 | 3356 | 109 | P/Ac/U/T/D | 465 | 23 | 103 | 2 | TF | Smad | P | 174 | x |
| Signal transducer and activator of transcription 3 (STAT3) | P40763 | 26 | 101 | P/Ac/T/D/Av | 770 | 9 | 55 | 4 | TF | JAK/STAT | P |
Abbreviations: Uniprot, Uniprot accession; HPRD, HPRD ID; PPI, number of PPIs; in the keyword column, P, phosphoprotein; Ac, acetylation; U, Ubl conjugation; T, transcription; D, DNA-binding; Av, activator: R, repressor; %ID, percentage of IDR; LID, length of the longest IDR; domain, number of domains; in the function column, TcoA, transcription co-activator; TF, transcription factor; PK, protein kinase; CB, chromatin binding; NR, nuclear receptor; TcoR, transcription co-repressor; in the process section, TC, transcription; Smad, Smad signaling pathway; MAPK, MAPK cascade; Notch, Notch signaling pathway; NR, nuclear receptor signaling pathway; NF-κΒ, NF-κΒ signaling pathway; JAK/STAT, JAK/STAT signaling pathway; TL, trigger of translocation into nucleus; P, phosphorylation; L, ligand binding; IDEAL, IDEAL identifier; in the ProS column, x, existence of protean segments.