Table 2. Hub proteins localized in both the cytoplasm and cell membrane, annotated by PTM’ or nucleotide-binding.

protein	Uniprot	HPRD	PPI	keyword	length	%ID	LID	TM	domains	function	process	step	IDEAL
Tyrosine-protein kinase Lck	P06239	1080	105	Ac/Nb/U	509	13	64	0	3	PK	T-Cell	2
E3 ubiquitin-protein ligase CBL	P22681	1320	85	U	906	53	426	0	5	UbL	Tyr-K	2	IID00300
Tyrosine-protein kinase SYK	P43405	2514	74	Nb/U	635	17	100	0	2	PK	B-cell	2
E3 ubiquitin-protein ligase SMURF1	Q9HCE7	6902	74	U	757	21	85	0	3	UbL	BMP	1	IID00328
Adapter molecule crk	P46108	1267	65	Ac	304	4	13	0	3	AP	Reeling	2
Mast/stem cell growth factor receptor Kit	P10721	1287	54	Nb/U	976	11	41	46	5	RC	VA	0
Tyrosine-protein kinase ZAP-70	P43403	1495	48	Ac/Nb	619	2	13	0	2	PK	T-Cell	1
Guanine nucleotide-binding protein G(i) subunit α-2	P04899	764	48	Nb	355	2	5	0	1	MD	VA	1

Abbreviations: Uniprot, Uniprot accession; HPRD, HPRD ID; PPI, number of PPIs; in the keyword column, Ac, acetylation; Nb, nucleotide-binding; U, Ubl conjugation; %ID, percentage of IDR; LID, length of the longest IDR; TM, length of the predicted trans-membrane regions; domains, number of domains; in the function column, PK, protein kinase; UbL, ubiquitin ligase; AP, adaptor in signaling pathways; RC, receptor; MD, Modulator in signaling pathways; in the process section, T-Cell, T-Cell signaling pathway; Tyr-K Tyrosine kinase signaling pathway; B-Cell, B-cell signaling pathway; BMP, BMP signaling pathway; Reeling, Reeling signaling pathway; VA, various signaling processes; step, number of steps from the cell membrane in KEGG pathway maps; IDEAL, IDEAL identifier.