Table 2. Weight loss of DB-1 human melanoma xenografts following treatment with nitrogen-mustards alone or in combination with LND.
| Experimental Groups | Ratio of Post-treatment: Pretreatment Weight (% Relative to Control) | ||
|---|---|---|---|
| Estimate (90% CI) | p value | ||
| Vs Control | Vs Single Agent | ||
| Alkylating Agent Alone | |||
| Chlorambucil | 89.4 | < 0.001 | NA |
| (86.1, 92.8) | |||
| Cyclophosphamide | 96.6 | 0.030 | NA |
| (93.8, 99.5) | |||
| Bendamustine | 93.2 | < 0.001 | NA |
| (91.3, 95.1) | |||
| Melphalan* | 92.0 | 0.011 | NA |
| (86.8, 97.4) | |||
| Alkylating Agent in Combination with LND | |||
| LND + Chlorambucil | 90.5 | < 0.001 | 0.627 |
| (87.1, 93.9) | |||
| LND + Cyclophosphamide | 92.6 | 0.001 | 0.015 |
| (89.7, 95.5) | |||
| LND+ Bendamustine | 84.7 | < 0.001 | < 0.001 |
| (83.0, 86.4) | |||
| LND + Melphalan* | 87.7 | 0.001 | 0.082 |
| (83.0, 92.6) | |||
Note: Ratio of minimum post-treatment to pre-treatment weight for each group, normalized to the ratio in the control group. P-values are for the comparison to control, and for the comparison of the combined LND (lonidamine)-alkylating agent to the alkylating agent alone. The mean weight at the start of treatment for animals in the current experiment was 30.1 g (95% CI 29.3, 30.3). For the control group the relative post- to pre-treatment weight was 97.0% (90% CI of 96.1, 97.9%).