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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Biochem J. 2015 Jul 8;470(2):233–242. doi: 10.1042/BJ20150548

Figure 2. R-carvedilol modifies the gating of single RyR2 channels.

Figure 2

Single rat RyR2 channels were recorded in quasi-physiological salt solutions. SR microsomes were pre-incubated for 1 h without (control) (A) or with (1 μM) R-carvedilol (B) before they were fused into the lipid bilayer with the drug in both the cytosolic and luminal solutions. Single control (n=7) and R-carvedilol-treated (n = 6) channels were recorded at −40 mV. Openings are downward. Baselines are indicated (short bars). All-point histograms (C), Po (D), OT (E), CT (F) and event frequency (s−1) (G) are shown (*P < 0.05; **P < 0.01 compared with control).