Table 4. Comparison of the beta-cell function and insulin sensitivity between women with a normal OGTT and women with glucose intolerance postpartum.
Normal N = 76 (56.3%) | Glucose intolerance N = 59 (43.7%) | P value | Adjusted p value | |
---|---|---|---|---|
ISSI-2 index (median) | 1.9(1.7–2.4) | 1.6(1.2–2.1) | <0.0001 | 0.002 |
Insulinogenic index/HOMA-IR index (median) | 0.010(0.008–0.014) | 0.009(0.005–0.015) | 0.119 | 0.249 |
Matsuda index (median) | 0.778(0.532–1.067) | 0.656(0.386–1.224) | 0.279 | 0.709 |
1/HOMA-IR index(median) | 0.004(0.003–0.007) | 0.004(0.002–0.009) | 0.699 | 0.384 |
ISSI-2: insulin secretion sensitivity index postpartum; Insulinogenic index/HOMA-IR is a measure for beta-cell function postpartum; Matsuda: insulin sensitivity index of Matsuda postpartum; 1/HOMA-IR: the reciprocal of the homeostasis model assessment of insulin resistance post-partum; Statistical analyzes: for non-parametric variables the Mann–Whitney’s U-test were used. The p-values for the measurements post-partum are adjusted for age, BMI, ethnicity and breastfeeding. P values in bold are statistical significant.