Table 2. Episode characteristics.
Rate outcomes were compared by arm between persons using generalized estimating equations with a log link. Continuous outcomes were compared using generalized estimating models with an identity link. Significant differences are noted in bold and are limited to differences in episode rate and episode duration. All other episode characteristics are equivalent across cohorts.
| Episode characteristics (n = 381) | HIV- (n = 173) | Test versus HIV- | HIV+CD4 >500 (n = 55) | HIV+CD4 200–500 (n = 95) | HIV+CD4 <200 (n = 58) |
|---|---|---|---|---|---|
| Annualized rate of episodes per year (n = 572) | 13 (n = 275) | Risk ratio (95% CI; p-value) | 1.0 (0.8, 1.4; 0.79)(n = 82) | 1.3 (1.0, 1.7; 0.056)(n = 125) | 1.5 (1.1, 2.0; 0.018)(n = 90) |
| Starting HSV DNA copy | 4.1 | Average difference (95% CI; p-value) | 0.0 (-0.5, 0.5; 0.95) | 0.2 (-0.2, 0.7; 0.31) | -0.4 (-1.0, 0.3; 0.26) |
| Ending HSV DNA copy | 3.3 | Average difference (95% CI; p-value) | 0.2 (-0.2, 0.6; 0.18) | 0.2 (-0.1, 0.5; 0.16) | 0.3 (-0.2, 0.8; 0.26) |
| Maximum copy (average) | 4.7 | Average difference (95% CI; p-value) | 0.2 (-0.4, 0.8; 0.48) | 0.2 (-0.4, 0.7; 0.50) | -0.4 (-1.0, 0.2; 0.15) |
| Upslope to maximum value (log 10 HSV DNA / day) | 4.3 | Average difference (95% CI; p-value) | -0.6 (-2.4, 1.3; 0.56) | -0.5 (-2.2, 1.2; 0.53) | -1.1 (-3.0, 0.9; 0.28) |
| Downslope from maximum value (log 10 HSV DNA / day) | -1.8 | Average difference (95% CI; p-value) | 0.4 (-0.2, 1.0; 0.20) | -0.7 (-1.6, 0.1; 0.10) | -0.4 (-1.8, 0.9; 0.54) |
| Duration using interval censoring (n = 547), days | 3.7(n = 260) | Log rank (p-value) | 4.6 (0.11)(n = 78) | 4.1 (0.38)(n = 123) | 5.5 (0.042)(n = 86) |
| Percent with lesions | 39 (23%) | Risk ratio (95% CI; p-value) | 0.7 (0.3, 1.4; 0.28) | 1.1 (0.7, 1.9; 0.70) | 0.9 (0.4, 1.9; 0.78) |
| Percent with no HSV rebound | 140 (81%) | Risk ratio (95% CI; p-value) | 0.9 (0.8, 1.1; 0.45) | 0.9 (0.8, 1.1; 0.32) | 1.0 (-0.9, 1.1; 0.96) |