Table 6. Part B of the Study.
Hematological variables.
| Time | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Clean | After donation | After RBC re-infusion | ||||||||
| Weeks 0, 1, 2 | Week 5 | Week 5 +2h | Week 5 +24h | Week 6 | Week 7 | Week 8 | Week 9 | |||
| Variable | MANOVA | Sex | N = 52 | N = 19 | N = 15 | N = 15 | N = 17 | N = 19 | N = 19 | N = 17 |
| Transferrin (g·L-1) | Time: F = 8.9, P = 0.0.03 | M+W | 2.4 ± 0.3 | 2.6 ± 0.3 | 2.5 ± 0.3 | 2.6 ± 0.4 | 2.7 ± 0.3 | 2.7 ± 0.3 | 2.7 ± 0.3 | 2.6 ± 0.3 |
| Iron (μmol·L-1) | Time: F = 0.004, P = 0.88 | M+W | 19 ± 7 | 15 ± 6 | 18 ± 6 | 16 ± 9 | 19 ± 9 | 18 ± 11 | 17 ± 6 | 20 ± 6 |
| Bilirubin (μmol·L-1) | Time: F = 0.04, P = 0.58 | M+W | 14 ± 5 | 13 ± 4 | 17 ± 5 | 16 ± 7 | 15 ± 7 | 14 ± 6 | 15 ± 7 | 15 ± 6 |
| Hemoglobin (g·L-1) | Sex*: F = 4.9, P<0.0001 | M | 148 ± 8† | 137 ± 8† | 143 ± 7† | 145 ± 6† | 148 ± 8† | 148 ± 8† | 150 ± 8† | 150 ± 8† |
| W | 126 ± 5 | 120 ± 8 | 125 ± 7 | 126 ± 9 | 124 ± 7 | 123 ± 6 | 126 ± 8 | 125 ± 8 | ||
| Leukocytes (109·L-1) | Time: F = 1.7, P = 0.30 | M+W | 6 ± 1 | 5 ± 1 | 5 ± 1 | 6 ± 1 | 6 ± 1 | 6 ± 1 | 6 ± 1 | 6 ± 1 |
| Neutrophils (109·L-1) | Time: F = 1.6, P = 0.70 | M+W | 3 ± 1 | 3 ± 1 | 3 ± 1 | 3 ± 1 | 3 ± 1 | 3 ± 1 | 3 ± 1 | 3 ± 1 |
| Lymphocytes (109·L-1) | Time: F = 0.8, P = 0.89 | M+W | 2 ± 1 | 2 ± 1 | 2 ± 0 | 2 ± 1 | 2 ± 1 | 2 ± 0 | 2 ± 1 | 2 ± 1 |
| Monocytes (109·L-1) | Time: F = 5.9, P = 0.24 | M+W | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.5 ± 0.1 |
| Eosinophils (109·L-1)* | Time: F = 3.8, P = 0.23 | M+W | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| Basophils 109·L-1)* | No statistics possible | M+W | 0.1 ± 0 | 0.1 ± 0 | 0.1 ± 0 | 0.1 ± 0 | 0.1 ± 0 | 0.1 ± 0 | 0.1 ± 0 | 0.1 ± 0 |
| Erythrocytes (1012·L-1) | Sex*: F = 2.4, P = 0.0004 | M | 5.0 ± 0.3† | 4.7 ± 0.3† | 4.8 ± 0.2† | 4.9 ± 0.2† | 5.0 ± 0.2† | 5.0 ± 0.3† | 5.1 ± 0.3† | 5.1 ± 0.3† |
| W | 4.3 ± 0.2 | 4.1 ± 0.4 | 4.2 ± 0.3 | 4.3 ± 0.4 | 4.2 ± 0.3 | 4.2 ± 0.3 | 4.3 ± 0.3 | 4.3 ± 0.4 | ||
| Thrombocytes (109·L-1) | Time: F = 9.9, P = 0.023 | M+W | 220 ± 35 | 210 ± 32 | 208 ± 37 | 221 ± 38 | 231 ± 44 | 233 ± 43# | 230 ± 41” | 224 ± 41 |
| EVF (%) | Sex*: F = 3.3, P<0.0001 | M | 43 ± 2† | 40 ± 2† | 42 ± 2† | 43 ± 2† | 44 ± 3† | 44 ± 3† | 44 ± 3† | 44 ± 2† |
| W | 38 ± 1 | 37 ± 3 | 38 ± 2 | 38 ± 3 | 38 ± 2 | 38 ± 2 | 38 ± 2 | 38 ± 3 | ||
| MCV (fL) | Time: F = 22, P<0.05 | 88 ± 5 | 88 ± 5 | 88 ± 5 | 89 ± 5 | 89 ± 5 | 88 ± 4 | 88 ± 5 | 87 ± 3 | |
| MCH (pg) | Time: F = 0.42, P = 0.004 | 30 ± 2 | 29 ± 2 | 30 ± 2 | 30 ± 2 | 30 ± 1 | 29 ± 2 | 30 ± 2 | 29 ± 1 | |
| MCHC (g·L-1) | Time: F = 39, P = 0.02 | M | 342 ± 8† | 342 ± 9† | 345 ± 9† | 342 ± 8† | 341 ± 11† | 340 ± 9† | 344 ± 7† | 342 ± 7† |
| W | 328 ± 6 | 323 ± 9 | 330 ± 7 | 325 ± 8 | 327 ± 6 | 324 ± 11 | 330 ± 6 | 325 ± 10 | ||
Mean ± SD. Repeated measure MANOVA (with Greenhouse-Geisser ε adjusted p-value if test for sphericity is significant) given for each variable. Time indicate significant change over time, men and women combined.
Time*Group indicate a difference in response between men and women. Sex indicate a difference between men and women, independent of Time.
#Significant difference from Clean at this time point (p<0.05 by oneway ANOVA).
†Significant difference between Men and Women (p<0.05 by oneway ANOVA).
EVF; Erythrocyte Volume Fraction, MCV; Mean Corpuscular Volume (of erythrocytes), MCH; Mean Corpuscular Hemoglobin Mass (of erythrocytes), MCHC; Mean Corpuscular Hemoglobin Concentration (of erythrocytes). M; Men, W; Women. If a significant difference between men and women was observed, data was split for effect over Time*Group. Statistics not possible due to repeated 0 value for basophils.