Table 4.

Molecular characterization of amino acid changes in the HA1 proteins of H3N2 isolates recovered from 2012–2013 season.

Isolate	Amino acid positiona
	2	8	33	45 (C)	48 (C)	53 (C)	94 (E)	128 (B)	142 (A)	144 (A)	145 (A)	158 (B)	198 (B)	199	223	278 (C)	280 (C)	312 (C)
WI/67	K	N	Q	S	T	D	Y	T	R	N	N	K	A	S	I	N	E	N
BR/10	K	N	Q	S	T	D	Y	T	R	N	N	K	A	S	V	N	E	N
PE/16	K	N	Q	S	T	D	Y	T	R	K	N	N	A	S	V	N	E	N
VI/361	K	N	Q	N	I	D	Y	T	R	N	N	N	S	S	I	N	E	S
TX/50	K	N	R	N	I	D	Y	N	R	N	N	N	P	S	I	K	E	S
MS/3	K	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/4	K	N	R	N	I	D	Y	A	G	N	S	N	S	S	I	K	E	S
MS/17	K	N	R	N	I	D	Y	A	G	N	S	N	S	S	I	K	E	S
MS/20	K	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/27	N	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/29	K	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/32	K	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/33	K	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/35	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/36	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/40	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/41	K	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/44	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/45	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/47	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/48	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/49	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/51	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/53	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N
MS/65	K	N	R	N	I	D	Y	T	R	N	S	N	S	S	I	K	E	S
MS/6	E	D	Q	S	T	N	H	T	R	N	N	N	A	S	V	N	A	N

^aThe antibody binding sites were annotated based on previous report (Wilson and Cox, 1990).