Figure 4. Pharmacological blockade of NALCN impairs SNr firing.
(A) Representative time course of SNr neuron firing rate with application of gadolinium (Gd3+; 100 μM). (B) Comparison of firing rates before and after Gd3+ application (8.2 ± 0.9 versus 0.6 ± 0.3 spikes/s; paired t-test; p=0.00018; n = 6). ***p<0.001.