Variable effect of pressure amplitude (ΔP), frequency (f), and nasal prong size on tidal volume (VT) delivery during test-lung simulated high-frequency nasal ventilation. (a) At a fixed frequency (10 Hz) and mean airway pressure (10 cmH2O), increasing ΔP is accompanied by increasing VT with an apparent plateau effect around 70% maximum amplitude. There is a significant increase in VT when the I:E ratio is increased from 33% to 50%. (Adapted with permission from De Luca et al. [20].) (b) With a set I:E ratio and ΔP, increasing high frequency breath rate is accompanied by decreasing VT. The effect on VT is affected by the caliber of the nasal prong interface. High frequency via 3100A (CareFusion, San Diego, CA, USA). (Adapted with permission from De Luca et al. [19].)