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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Semin Fetal Neonatal Med. 2016 Feb 18;21(3):162–173. doi: 10.1016/j.siny.2016.02.001

Fig. 8.

Fig. 8

Histopathology at 21 days of preterm lambs (131 days) supported by (a) invasive mechanical ventilation (IMV) or (b) non-invasive high-frequency nasal ventilation (HFNV). The terminal respiratory unit (TRU) is dilated and non-uniform in MV animals compared to HFNV lambs. Blunted secondary crest formation is seen in the lungs of MV lambs (large arrowhead, a) but numerous well-developed secondary crests are noted in the HFNV lambs (large arrowhead, b). The arrows point to thickened saccular/alveolar walls in the lambs managed by IMV contrasted to thin distal airspace walls in the HFNV lambs.