Table 1.
List of confident hits. This table shows the rank, associated genes, SoSix1 motif locations predicted by i-cisTarget and ChIP-Seq data validation, as well as reporter assay results and corresponding human homologues. Gray highlights indicate motif predictions for which no corresponding Gal4 lines were available.
| Rank | Associated genes | i-cis Target predicted So binding region | Overlap with So ChIP peak? | Reporter assay Positive? | Human homologue |
|---|---|---|---|---|---|
| 14 | HLHmdelta | chr3R: 21822368-21823453 | YES | YES | N/A |
| 17 | Mmp2 | chr2R: 5547784-5548876 | YES | N/A | MMP |
| 26 | hh | chr3R: 18962365-18964702 | YES | YES | SHH |
| 48 | so | chr2R: 3316058-3317633 | NO | NO | SIX1-6 |
| 63 | betaTub97EF | chr3R: 23801615-23803245 | YES | N/A | TUBB1 |
| 85 | so | chr2R: 3314710-3315493 | YES | YES | SIX1-6 |
| 143 | so | chr2R: 3304563-3305585 | NO | NO | SIX1-6 |
| 144 | eya | chr2L: 6549825-6550357 | NO | YES (ocelli) | EYA1-4 |
| 180 | eya | chr2L: 6544459-6546448 | NO | NO | EYA1-4 |
| 228 | CG10936 | chr2R: 13515427-13516089 | YES | N/A | N/A |
| 266 | fz2 | chr3L: 19161223-19162160 | YES | N/A | FZD1-10 |
| 278 | rau | chr2L: 5869522-5870420 | NO | N/A | N/A |
| 279 | eya | chr2L: 6541716-6543559 | YES | NO | EYA1-4 |
| 307 | Mmp2 | chr2R: 5541749-5544247 | YES | N/A | MMP |
| 377 | fz2 | chr3L: 19176425-19177998 | YES | N/A | FZD1-10 |
| 503 | E2f | chr3R: 17471133-17472022 | YES | YES | E2F1 |
| 529 | dsx-c73A | chr3L: 16428779-16430005 | NO | N/A | N/A |
| 645 | fz2 | chr3L: 19200054-19200895 | NO | N/A | FZD1-10 |
| 676 | E2f | chr3R: 17475343-17476006 | YES | YES | E2F1 |
| 732 | pnt | chr3R: 19145518-19146845 | YES | YES | ETS1-2 |
| 775 | fz2 | chr3L: 19140486-19141324 | NO | N/A | FZD1-10 |