Table 2.

A dose response comparison of the model predictions of a single exposure (i.e., 0.001, 10, 100, and 1,000 ng of TCDD/kg of body weight) to discriminate between the routes of elimination. The exposure scenario for each simulation assumes a woman was 20 years old at the start of the exposure, that pregnancy began 1 year after the single exposure and lasted for 280 days, and that lactation lasted for 6 months (180 days) starting just after the labor. The simulation was stopped 3 years post-exposure. The following different conditions were simulated: pregnancy + lactation (P+L), pregnancy and no lactation (P+NL), and no pregnancy and no lactation (NP+NL). The following three different parameters were retained for this comparison: the body burden (ng/kg), the whole blood TCDD concentration (ng/L), and the serum TCDD concentration (ng/kg in lipid adjusted).

Single Exposure Dose (ng/kg of Body Weight)	Dose Metrics	P+L	P+NL	NP+NL
0.001 ng/kg	Body burden (ng/kg of body weight)	7.56×X10−4	8.01×10−4	8.01×10−4
	Whole blood TCDD (ng/L)	2.58×10−5	2.60×10−5	2.60×10−5
	Serum TCDD concentration (ng/kg lipid adjusted)	8.24×10−3	8.30×10−3	8.30×10−3
10 ng/kg	Body burden (ng/kg of body weight)	6.4215	6.45	6.45
	Whole blood TCDD (ng/L)	0.16	0.164	0.16
	Serum TCDD concentration (ng/kg lipid adjusted)	51.97	52.16	52.21
100 ng/kg	Body burden (ng/kg of body weight)	52.00	52.16	52.19
	Whole blood TCDD (ng/L)	0.94	0.95	0.95
	Serum TCDD concentration (ng/kg lipid adjusted)	301.223	301.944	302.104
1,000 ng/kg	Body burden (ng/kg of body weight)	430.19	430.19	430.90
	Whole blood TCDD (ng/L)	4.766	4.77	4.77
	Serum TCDD concentration (ng/kg lipid adjusted)	1520.26	1520.26	1522.14