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. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: Cancer Lett. 2015 Dec 10;380(1):319–329. doi: 10.1016/j.canlet.2015.12.003

Figure 1. Complexity of the tumor microenvironment.

Figure 1

TME poses multi-faceted barriers to drugs transport owing to the dense stromal tissue which is composed of collagens, fibronectin, and hyaluronan, an abundance of cancer-associated fibroblasts, and aberrant interactions between infiltrating tumor-associated immune cells, cancer cells, and CAFs.