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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: Life Sci. 2015 Dec 10;159:140–143. doi: 10.1016/j.lfs.2015.12.022

Fig. 1. Effect of ET-1 on calcium influx in cultured SMC.

Fig. 1

(A) Representative electrophysiological recording showing the activity of single calcium channels obtained in cultured primary renal SMCs before and after ET-1 treatment (100 nM). Current trace was recorded at −80 mV holding potential. Insets show current traces with expanded scales. (B) Primary renal SMCs loaded with fluorescent Ca2+ indicator Fura 2-AM before and after ET-1 treatment. (C) ET-1 produced dynamic changes in cytosolic Ca2+ concentration in SMC. Presented are average time courses of [Ca2+]i changes in individual SMC following exposure to ET-1 (100 nM).