TABLE I.

Number of excess hydration water for lysozyme and myoglobin computed as $N_{\mathit{ex}-\mathit{hyd}}={\tilde{F}}_{\mathit{hyd}}\left(0\right)/10$. Those numbers are very close to the values computed by integration all over the hydration shells. For lysozyme, RISM-KH values are 71.7 vs. 71.9.

Protein	RISM-KH	RISM-PSE2	RISM-PSE3	MD	SAXS
Lysozyme	71.7	83.5	92.9	48.1	50 ± 1
Myoglobin	86.5	101.4	113.0	53.1	60 ± 2