Table 1.

Repeatability and treatment effects for three main pharmacokinetic (PK) parameters as measured from our comparative analysis of arterial input function (AIF) methods

	AIF	Number of patients	CoV (%)	Treatment effects
				(% decrease)	P value	No. outside LoA
Ktrans	POP	13	7.5	49.5	0.023	11
	DCE	10	23.7	57.0	0.043	6
	PB	13	21.0	65.7	0.021	10
	CT	13	11.8	58.9	0.0049	11
ve	POP	13	11.0	32.6	0.082	4
	DCE	10	10.9	47.9	0.048	6
	PB	13	22.4	45.3	0.18	5
	CT	13	18.4	36.7	0.041	5
vp	POP	13	62.5	29.7	0.064	0
	DCE	10	50.4	14.5	0.6	0
	PB	13	86.8	48.0	0.021	0
	CT	13	54.2	37.4	0.085	1

POP population, DCE dynamic contrast enhanced, PB pre-bolus, CT computed tomography, LoA limits of agreement, CoV coefficient of variation, K ^trans transfer coefficient between blood plasma and extravascular extracellular space, v _e volume of extravascular extracellular space, v _p volume of vascular plasma space