. 2016 May 1;16(11):1–202.

Table 23:

Clinical Outcomes in Studies Evaluating the Effectiveness of Vertebral Augmentation for Vertebral Hemangiomas

Author, Year Country	Patients, N VB Levels Treated, n	Pain Intensity, VAS Mean ± SD (Range)^a	Analgesic Use	Mobility	Pain-Related Disability Health-Related Quality of Life
Vertebroplasty for Vertebral Hemangiomas
Acosta et al, 2006¹⁶⁵ United States	4 of 16 patients with pain and without neurological symptoms	Baseline NR Post-intervention Decreased pain in 3 patients; 1 with initial improvement had recurrence of mild back pain at follow-up	NR	NR	NR
Fuwa et al, 2006¹⁶⁴ Japan	1 patient T10, neural arch	Baseline 9.0 Post-intervention (24 hours) 1.0	NR	Baseline Increasing back instability and unable to walk without a corset Post-intervention Walking comfortably without corset support	NR
Guarnieri et al, 2009¹⁶⁹ Italy	24 patients 36 VB levels that were symptomatic but not aggressive (n = 18), symptomatic and MRI-detected signs of aggressiveness (n = 4), symptomatic with epidural compression (n = 2)	Baseline NR Post-intervention Complete resolution of pain within 24 or 72 hours (VAS NR)	NR	NR	Baseline NR Post-intervention Within 24–72 hours, ODI < 40% in all patients
Hao et al, 2012¹⁷⁰ China	26 patients 28 VB levels (17 T, 11 L)	Baseline 7.4 ± 1.6 Post-intervention 24 hours: 1.7 ± 0.6, P < .05 3 months: 0.7 ± 0.4	NR	NR	SF-36, mean ± SD Baseline PFS score f: 18.4 ± 4.6 MHS score: 20.6 ± 4.4 Post-intervention (24 hours) PFS score: 27.4 ± 3.5, P < .05 MHS score: 23.5 ± 2.2, P < .05
Jian, 2013¹⁷⁴ China	8 patients 8 VB levels (2 C3, 3 C4, 2 C5, 1 C6) with neck and/or shoulder pain without radiculopathy or myelopathy	Baseline 6.9 ± 0.6 Post-intervention 24 hours: 1.3 ± 0.5, P < .01 Last follow-up: 1.2 ± 0.5	NR	NR	NR
Jiang et al, 2014¹⁶⁸ China	9 of 29 patients Vertebral hemangioma and neurological deficits; 9 treated with VP (VP and RT [n = 1], VP and decompression surgery [n = 2], VP and RT and decompression surgery [n = 6])	NR	NR	NR	NR
Kyphoplasty for Vertebral Hemangiomas
Atalay et al, 2006¹⁷⁵ Turkey	1 patient KP for sacrum and subsequently L3	Baseline 9.0 Post-intervention (24 hours) 0	NR	Baseline Unable to walk due to pain Post-intervention Able to walk without pain	NR
Hadjipavlou et al, 2007¹⁷³ Greece	6 patients KP (n = 4), KP and surgery (n = 2, 11 VB levels); symptomatic and aggressive (n = 4)	Baseline 8.0 Post-intervention (24 hours) 1.7 Pain was immediately relieved in all patients post-operatively	NR	Baseline 1 patient was paraplegic Frankel B partial sensory deficit Post-intervention NR	ODI, mean (range) Baseline 40% (30%–60%) Post-intervention 10% (0%–20%)
Jones et al, 2009¹⁷¹ United States	2 patients KP at 2 VB levels, L5, T12	Baseline Patient 1: NR Patient 2: 10.0 Post-intervention Patient 1: 0 Patient 2: middle and lower back pain totally resolved	Baseline Patient 1: epidural steroid injections and dorsal column nerve stimulator for pain Patient 2: lumbosacral median branch nerve blocks, RFA and trigger point injections Post-intervention NR	NR	Baseline NR Post-intervention Patient 1: resumed all previous activities due to significant pain relief Patient 2: NR
Zapalowicz et al, 2008¹⁷² Poland	1 patient KP at C7 without neurological deficit or cord involvement, but with disrupted posterior VB wall	Baseline 8.0; persistent neck pain increasing with motion, upper extremity numbness and frequent headaches Post-intervention VAS NR; at 24 hours, pain completely disappeared	NR	NR	Baseline NR Post-intervention Patient resumed former social and professional life

Abbreviations: C, cervical; KP, kyphoplasty; L, lumbar; MHS, mental health component summary score; MRI, magnetic resonance imaging; NR, not reported; ODI, Oswestry Disability Index; PFS, physical functioning score; RFA, radiofrequency ablation; RT, radiation therapy; SD, standard deviation; SF-36, Short-Form Health Survey; T, thoracic; VAS, visual analogue scale; VB, vertebroplasty.

Unless otherwise indicated.