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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Pain Manag Nurs. 2016 Jun;17(3):181–196. doi: 10.1016/j.pmn.2016.03.003

Table 3.

Model Path Estimates for Genes and significant pain associated SNPs (NS = nonsignificant path)

Genes BDNF FKBP5 NTRK2
SNPs rs11602246 rs16878806 rs16879378 rs1475774 rs4142910 rs11140755 rs12340748 rs10780688
Risk allele a C G C T A C C G
Model Paths Path P* Path P* Path P* Path P* Path P* Path P* Path P* Path P*
total pain areas <--- SNP −.169 .016 .146 .035 .170 .013 .145 .038 NS NS −.146 .036 −.146 .036 .164 .019
total pain intensity <--- SNP NS NS NS NS NS NS NS NS −.143 .044 NS NS NS NS NS NS
total pain areas <--- age −.222 .002 −.188 .007 −.171 .012 −.207 .003 −.227 .001 −.198 .005 −.198 .005 −.235 .001
total pain areas <--- cognition .393 .001 .440 .001 .464 .001 .424 .001 .405 .001 .423 .001 .423 .001 .392 .001
total pain areas <--- body mass index .144 .001 .142 .001 .136 .002 .136 .002 .144 .001 .143 .001 .143 .001 .141 .002
total pain intensity <--- age −.195 .006 −.166 .020 −.168 .018 −.187 .009 −.199 .005 −.174 .014 −.174 .014 −.204 .004
total pain intensity <--- cognition .312 .001 .327 .001 .329 .001 .316 .001 .303 .001 .321 .001 .321 .001 .299 .001
upper extremity ADL <--- cognition −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.678 .001
lower extremity ADL <--- cognition −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001
lower extremity ADL <--- age .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016
Gene NTRK2
SNP rs7019555 rs4631550 rs1565447 rs1565446 rs1565445 rs10125469 rs7045296 rs7030960
Risk Allele A A G G T G A C
Model Paths Path P* Path P* Path P* Path P* Path P* Path P* Path P* Path P*
total pain areas <--- SNP NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS
total pain intensity <--- SNP −.139 .050 −.139 .050 .139 .050 .139 .050 .139 .050 −.139 .050 −.139 .050 −.139 .050
total pain areas <--- age −.228 .001 −.228 .001 −.228 .001 −.228 .001 −.228 .001 −.228 .001 −.228 .001 −.228 .001
total pain areas <--- cognition .404 .001 .404 .001 .404 .001 .404 .001 .404 .001 .404 .001 .404 .001 .404 .001
total pain areas <--- body mass index .144 .001 .144 .001 .144 .001 .144 .001 .144 .001 .144 .001 .144 .001 .144 .001
total pain intensity <--- age −.200 .005 −.200 .005 −.200 .005 −.200 .005 −.200 .005 −.200 .005 −.200 .005 −.200 .005
total pain intensity <--- cognition .302 .001 .302 .001 .302 .001 .302 .001 .302 .001 .302 .001 .302 .001 .302 .001
upper extremity <--- cognition −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001
lower extremity ADL <--- cognition −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001
lower extremity ADL <--- age .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016
Gene NTRK2 NTRK3
SNP rs7857957 rs1490406 rs1490405 rs1490404 rs10123600 rs41277883b rs17765281 rs11634388
Risk Allele G C G A C C G
Model Paths Path P* Path P* Path P* Path P* Path P* Path P* Path P* Path P*
total pain areas <--- SNP NS NS NS NS NS NS NS NS NS NS NS NS −.148 .036 .180 .009
total pain intensity <--- SNP .143 .044 −.143 .044 .143 .044 −.143 .044 −.143 .044 −.139 .047 NS NS .148 .036
total pain areas <--- age −.227 .001 −.227 .001 −.227 .001 −.227 .001 −.227 .001 −.232 .001 −.210 .003 −.211 .002
total pain areas <--- cognition .405 .001 .405 .001 .405 .001 .405 .001 .405 .001 .420 .001 .399 .001 .430 .001
total pain areas <--- body mass index .144 .001 .144 .001 .144 .001 .144 .001 .144 .001 .139 .002 .149 .001 .139 .002
total pain intensity <--- age −.199 .005 −.199 .005 −.199 .005 −.199 .005 −.199 .005 −.204 .003 −.190 .008 −.188 .008
total pain intensity <--- cognition .303 .001 .303 .001 .303 .001 .303 .001 .303 .001 .345 .001 .318 .001 .319 .001
upper extremity <--- cognition −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001
lower extremity ADL <--- cognition −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.470 .001 −.469 .001 −.469 .001
lower extremity ADL <--- age .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016
Gene NTRK3 OXTR
SNP rs16941001 rs16941392 rs8033396 rs1863482 rs11073768 rs2270465
Risk Allele A G G C G G
Model Paths Path P* Path P* Path P* Path P* Path P* Path P*
total pain areas <--- SNP −.152 .030 .141 .043 .141 .046 NS NS NS NS NS NS
total pain intensity <--- SNP NS NS .141 .047 NS NS −.138 .053 .140 .048 .165 .019
total pain areas <--- age −.239 .001 −.193 .006 −.217 .002 −.224 .001 −.239 .001 −.225 .001
total pain areas <--- cognition .395 .001 .433 .001 .405 .001 .407 .001 .396 .001 .407 .001
total pain areas <--- body mass index .145 .001 .146 .001 .145 .001 .140 .002 .142 .002 .143 .001
total pain intensity <--- age −.208 .003 −.168 .018 −.190 .008 −.196 .006 −.213 .003 −.196 .005
total pain intensity <--- cognition .314 .001 .330 .001 .315 .001 .307 .001 .296 .001 .315 .001
upper extremity <--- cognition −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001 −.679 .001
lower extremity ADL <--- cognition −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001 −.469 .001
lower extremity ADL <--- age .178 .016 .178 .016 .178 .016 .178 .016 .178 .016 .178 .016
*

p significant at ≤ .05

Note:

a

Risk allele: (the more copies of this allele, the more pain intensity or areas reported)

b

rs41277883, a potentially functional variant, was tested as part of a secondary analysis and not part of the GWAS platform