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. 2016 Jun 10;6:41. doi: 10.1186/s13578-016-0108-4

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A PB insertion effectively abolished Otg1 expression. a Schematic representation of the genomic sequence flanking PB insertion site in Otg1. White box: exon. b Western blot did not detect OTG1 expression in either E13.5 Otg1 ^PB/PB embryos or tissues of P1 Otg1 ^PB/PB mice. c Immunofluorescence staining showed co-localization of OTG1 protein and Giantin in both pancreatic tissues of MEFs from wild-type mice