. 2016 Jun 10;13:40. doi: 10.1186/s12977-016-0272-y

Table 3.

Maternal FcγR variants associated with perinatal HIV-1 transmission after adjusting for confounding variables

	Total transmitting				Intrapartum transmitting
	Univariate	Adjusted for VL^a		P_Bonf	Univariate	Adjusted for VL		P_Bonf
	Univariate	AOR (95 % CI)	P value	P_Bonf	Univariate	AOR (95 % CI)	P value	P_Bonf
FcγRIIa (rs1801274)
Genotype
131HH (ref)		1				1
131HR	P = 0.378	1.81 (0.82–3.99)	P = 0.141	ns	P = 0.558	1.43 (0.46–4.46)	P = 0.539	ns
131RR	P = 0.172	2.59 (1.14–5.87)	P = 0.023	ns	P = 0.371	2.57 (0.80–8.26)	P = 0.113	ns
Allele carriage
≥1 131H allele	P = 0.288	0.58 (0.33–1.05)	P = 0.071	ns	P = 0.464	0.49 (0.21–1.16)	P = 0.106	ns
≥1 131R allele	P = 0.233	2.11 (1.00–4.42)	P = 0.049	ns	P = 0.449	1.82 (0.64–5.23)	P = 0.263	ns
FcγRIIb (rs1050501)
Genotype
232II (ref)		1				1
232IT	P = 0.450	1.29 (0.71–2.35)	P = 0.408	ns	P = 0.442	1.60 (0.65–3.93)	P = 0.309	ns
232TT	P = 0.075	2.80 (1.11–7.10)	P = 0.030	ns	P = 0.242	3.25 (0.87–12.17)	P = 0.080	ns
Allele carriage
≥1 232I allele	P = 0.103	0.41 (0.17–0.97)	P = 0.043	ns	P = 0.239	0.40 (0.12–1.33)	P = 0.133	ns
≥1 232T allele	P = 0.231	1.49 (0.84–2.62)	P = 0.171	ns	P = 0.317	1.81 (0.77–4.28)	P = 0.175	ns
FcγRIIIa (rs396991)
Genotype
158F/FF/FF (ref)		1				1
158FV/FFV/FVV	P = 0.010	0.51 (0.28–0.92)	P = 0.026	ns	P = 0.672	1.09 (0.45–2.64)	P = 0.850	ns
158V/VV	P = 0.041	0.30 (0.11–082)	P = 0.018	ns	P = 0.266	0.20 (0.02–1.70)	P = 0.141	ns
Allele carriage
≥1 158F allele	P = 0.217	2.29 (0.89–5.88)	P = 0.084	ns	P = 0.183	5.22 (0.67–40.41)	P = 0.114	ns
≥1 158V allele	P = 0.004	0.46 (0.26–0.82)	P = 0.008	ns	P = 0.980	0.89 (0.37–2.12)	P = 0.786	ns
FcγRIIIb
Genotype
HNA1a+/1b−/1c−	P = 0.315	0.47 (0.20–1.10)	P = 0.083	ns	P = 0.276	0.45 (0.12–1.61)	P = 0.218	ns
HNA1a−/1b+/1c−	P = 0.668	0.90 (0.33–2.46)	P = 0.839	ns	P = 0.837	1.31 (0.35–4.87)	P = 0.683	ns
HNA1a−/1b−/1c+	–	–			–	–
HNA1a+/1b+/1c− (ref)		1				1
HNA1a+/1b−/1c+	P = 0.448	0.63 (0.26–1.51)	P = 0.300	ns	P = 0.727	0.68 (0.19–2.42)	P = 0.547	ns
HNA1a−/1b+/1c+	P = 0.066	1.37 (0.59–3.19)	P = 0.466	ns	P = 0.502	1.20 (0.35–4.15)	P = 0.777	ns
HNA1a+/1b+/1c+	P = 0.849	0.42 (0.10–1.71)	P = 0.226	ns	P = 0.916	0.42 (0.05–3.72)	P = 0.433	ns
Allele carriage
≥1 HNA1a allotype	P = 0.369	0.78 (0.43–1.44)	P = 0.433	ns	P = 0.648	0.73 (0.30–1.75)	P = 0.481	ns
≥1 HNA1b allotype	P = 0.025	2.11 (1.16–3.85)	P = 0.014	ns	P = 0.099	2.18 (0.90–5.33)	P = 0.086	ns
≥1 HNA1c allotype	P = 0.599	0.95 (0.54–1.68)	P = 0.865	ns	P = 0.869	0.88 (0.38–2.04)	P = 0.759	ns

	In utero transmitting				In utero-enriched transmitting
	Univariate	Adjusted for VL + bwt		P_Bonf	Univariate	Adjusted for VL		P_Bonf
	Univariate	AOR (95 % CI)	P value	P_Bonf	Univariate	AOR (95 % CI)	P value	P_Bonf
FcγRIIa (rs1801274)
Genotype
131HH (ref)		1				1
131HR	P = 0.241	5.74 (0.66–49.93)	P = 0.113	ns	P = 0.447	2.28 (0.84–6.17)	P = 0.105	ns
131RR	P = 0.085	11.46 (1.29–101.86)	P = 0.029	ns	P = 0.225	2.82 (1.01–7.89)	P = 0.048	ns
Allele carriage
≥1 131H allele	P = 0.143	0.34 (0.12–0.97)	P = 0.045	ns	P = 0.383	0.63 (0.32–1.27)	P = 0.200	ns
≥1 131R allele	P = 0.136	7.65 (0.94–62.32)	P = 0.057	ns	P = 0.314	2.50 (0.97–6.40)	P = 0.057	ns
FcγRIIb (rs1050501)
Genotype
232II (ref)						1
232IT	P = 0.434	0.67 (0.22–2.06)	P = 0.487	ns	P = 0.678	1.15 (0.56–2.35)	P = 0.707	ns
232TT	P = 0.153	3.38 (0.73–15.61)	P = 0.119	ns	P = 0.121	2.57 (0.85–7.74)	P = 0.094	ns
Allele carriage
≥1 232I allele	P = 0.072	0.25 (0.06–1.07)	P = 0.062	ns	P = 0.133	0.42 (0.15–1.18)	P = 0.100	ns
≥1 232T allele	P = 0.883	0.93 (0.34–2.54)	P = 0.891	ns	P = 0.403	1.33 (0.67–2.61)	P = 0.412	ns
FcγRIIIa (rs396991)
Genotype
158F/FF/FF (ref)		1				1
158FV/FFV/FVV	P = 0.108	0.60 (0.21–1.71)	P = 0.341	ns	P = 0.0001	0.29 (0.14–0.63)	P = 0.002	ns
158V/VV	P = 0.115	0.19 (0.02–1.68)	P = 0.135	ns	P = 0.069	0.34 (0.11–0.98)	P = 0.046	ns
Allele carriage
≥1 158F allele	P = 0.222	4.01 (0.48–33.16)	P = 0.198	ns	P = 0.562	1.71 (0.61–4.80)	P = 0.305	ns
≥1 158V allele	P = 0.048	0.50 (0.18–1.36)	P = 0.174	ns	P = 0.0001	0.31 (0.15–0.62)	P = 0.001	0.042
FcγRIIIb
Genotype
HNA1a+/1b−/1c−	P = 0.155	1.44 (0.30–6.85)	P = 0.644	ns	P = 0.612	0.45 (0.16–1.24)	P = 0.124	ns
HNA1a−/1b+/1c−	P = 0.971	1.26 (0.12–13.63)	P = 0.851	ns	P = 0.429	0.66 (0.17–2.56)	P = 0.544	ns
HNA1a−/1b−/1c+	–	–			–	–
HNA1a+/1b+/1c− (ref)		1				1
HNA1a+/1b−/1c+	P = 0.267	1.88 (0.37–9.46)	P = 0.442	ns	P = 0.448	0.59 (0.20–1.68)	P = 0.321	ns
HNA1a−/1b+/1c+	P = 0.028	3.10 (0.60–15.95)	P = 0.177	ns	P = 0.047	1.53 (0.58–4.02)	P = 0.388	ns
HNA1a+/1b+/1c+	P = 0.562	1.10 (0.10–12.45)	P = 0.939	ns	P = 0.723	0.44 (0.08–2.28)	P = 0.326	ns
Allele carriage
≥1 HNA1a allotype	P = 0.638	0.85 (0.28–2.63)	P = 0.783	ns	P = 0.388	0.79 (0.38–1.64)	P = 0.523	ns
≥1 HNA1b allotype	P = 0.659	1.09 (0.39–3.02)	P = 0.868	ns	P = 0.085	2.23 (1.08–4.62)	P = 0.031	ns
≥1 HNA1c allotype	P = 0.262	1.51 (0.55–4.14)	P = 0.420	ns	P = 0.560	1.04 (0.53–2.06)	P = 0.904	ns

^aThe multivariate analysis adjusted for demographic and clinical variables that independently associated with transmission. Due to high correlation with viral load, CD4 T cell counts were not included in the multivariate model

P values less than 0.05 are indicated in italics

P _Bonf Bonferroni corrected P value, AOR adjusted odds ratio, CI confidence interval, VL viral load, bwt birth weight, ns not statistically significant, –, the variable of interest was not detected in any of the cases and thus could not be analysed