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. 2016 Jun 10;13:40. doi: 10.1186/s12977-016-0272-y

Table 4.

FcγR genotypes and allele carriage in HIV-1 exposed-uninfected and infected infants

Exposed-uninfected Total infected Intrapartum infected
N (%) N (%) OR (95 % CI) P value PBonf N (%) OR (95 % CI) P value PBonf
FcγRIIa (rs1801274) Overall association P = 0.704 ns P = 0.907 ns
Genotype
 131HH (ref) 47 (20.0) 19 (24.4) 1 7 (22.6) 1
 131HR 116 (49.4) 36 (46.2) 0.77 (0.40–1.47) P = 0.426 ns 14 (45.2) 0.81 (0.31–2.13) P = 0.670 ns
 131RR 72 (30.6) 23 (29.5) 0.79 (0.39–1.61) P = 0.516 ns 10 (32.3) 0.93 (0.33–2.62) P = 0.895 ns
Allele carriage
 ≥1 131H allele 163 (69.4) 55 (70.5) 1.06 (0.60–1.85) P = 0.848 ns 21 (67.7) 0.93 (0.42–2.07) P = 0.854 ns
 ≥1 131R allele 188 (80.0) 59 (75.6) 0.76 (0.42–1.43) P = 0.414 ns 24 (77.4) 0.86 (0.35–2.11) P = 0.737 ns
FcγRIIb (rs1050501) Overall association P = 0.278 ns P = 0.773 ns
Genotype
 232II (ref) 116 (49.4) 33 (42.3) 1 14 (45.2) 1
 232IT 90 (38.3) 30 (38.5) 1.17 (0.67–2.06) P = 0.583 ns 12 (38.7) 1.10 (0.49–2.51) P = 0.811 ns
 232TT 29 (12.3) 15 (19.2) 1.82 (0.87–3.79) P = 0.110 ns 5 (16.1) 1.43 (0.48–4.29) P = 0.525 ns
Allele carriage
 ≥1 232I allele 206 (86.8) 63 (78.6) 0.59 (0.30–1.17) P = 0.132 ns 26 (83.9) 0.73 (0.26–2.06) P = 0.554 ns
 ≥1 232T allele 119 (47.2) 45 (55.7) 1.33 (0.79–2.23) P = 0.280 ns 17 (54.8) 1.18 (0.56–2.51) P = 0.660 ns
FcγRIIIa (rs396991) Overall association P = 0.339 ns P = 0.964 ns
Genotype
 158F/FF/FF (ref) 86 (36.6) 34 (43.6) 1 12 (38.7) 1
 158FV/FFV/FVV 118 (50.2) 38 (48.7) 0.81 (0.47–1.40) P = 0.456 ns 15 (48.4) 0.91 (0.41–2.04) P = 0.821 ns
 158V/VV 31 (13.2) 6 (7.7) 0.49 (0.19–1.28) P = 0.145 ns 4 (12.9) 0.92 (0.28–3.08) P = 0.899 ns
Allele carriage
 ≥1 158F allele 194 (82.6) 72 (92.3) 0.75 (0.44–1.26) P = 0.272 ns 27 (87.1) 0.91 (0.42–1.97) P = 0.819 ns
 ≥1 158V allele 149 (63.4) 44 (56.4) 1.82 (0.73–4.55) P = 0.198 ns 19 (61.3) 1.03(0.34–3.13) P = 0.964 ns
FcγRIIIb Overall association P = 0.046 ns P = 0.023 ns
Genotype
 HNA1a+/1b−/1c− 58 (24.7) 9 (11.5) 0.42 (0.18–0.96) P = 0.040 ns 2 (6.5) 0.19(0.04–0.89) P = 0.035 ns
 HNA1a−/1b+/1c− 25 (10.6) 7 (9.0) 0.76 (0.29–1.95) P = 0.565 ns 1 (3.2) 0.22 (0.03–1.81) P = 0.160 ns
 HNA1a−/1b−/1c+ 14 (6.0) 4 (5.1) 0.77 (0.23–2.55) P = 0.672 ns 0 (0) –
 HNA1a+/1b+/1c− (ref) 73 (31.2) 27 (34.6) 1 13 (41.9) 1
 HNA1a+/1b−/1c+ 36 (15.3) 11 (14.1) 0.83 (0.37–1.85) P = 0.643 ns 7 (22.6) 1.09 (0.40–2.97) P = 0.863 ns
 HNA1a−/1b+/1c+ 22 (9.4) 13 (16.7) 1.60 (0.71–3.61) P = 0.260 ns 7 (22.6) 1.79 (0.63–5.03) P = 0.272 ns
 HNA1a+/1b+/1c+ 7 (3.0) 7 (9.0) 2.70 (0.87–8.43) P = 0.086 ns 1 (3.2) 0.80 (0.09–7.07) P = 0.843 ns
Allele carriage
 ≥1 HNA1a allotype 174 (74.0) 54 (69.2) 0.79 (0.45–1.38) P = 0.408 ns 23 (74.2) 1.01 (0.43–2.37) P = 0.986 ns
 ≥1 HNA1b allotype 127 (54.0) 54 (69.2) 1.91 (1.11–3.30) P = 0.020 ns 22 (71.0) 2.08 (0.92–4.70) P = 0.079 ns
 ≥1 HNA1c allotype 79 (33.6) 35 (44.9) 1.61 (0.95–2.71) P = 0.075 ns 15 (48.4) 1.85 (0.87–3.94) P = 0.110 ns
In utero infected In utero-enriched infected
N (%) OR (95 % CI) P value PBonf N (%) OR (95 % CI) P value PBonf
FcγRIIa (rs1801274) P = 0.265 ns P = 0.693 ns
Genotype
 131HH (ref) 4 (21.1) 1 12 (25.5) 1
 131HR 6 (31.6) 0.61 (0.16–2.25) P = 0.456 ns 22 (46.8) 0.74 (0.34–1.62) P = 0.455 ns
 131RR 9 (47.4) 1.47 (0.43–5.04) P = 0.541 ns 13 (27.7) 0.71 (0.30–1.68) P = 0.433 ns
Allele carriage
 ≥1 131H allele 10 (52.6) 0.49 (0.19–1.26) P = 0.139 ns 34 (72.3) 1.16 (0.58–2.32) P = 0.685 ns
 ≥1 131R allele 15 (78.9) 0.94 (0.30–2.96) P = 0.912 ns 35 (74.5) 0.73 (0.35–1.51) P = 0.396 ns
FcγRIIb (rs1050501) P = 0.083 ns P = 0.218 ns
Genotype
 232II (ref) 7 (36.8) 1 19 (40.4) 1
 232IT 6 (31.6) 1.10 (0.36–3.40) P = 0.862 ns 18 (38.3) 1.22 (0.61–2.46) P = 0.577 ns
 232TT 6 (31.6) 3.43 (1.07–10.98) P = 0.038 ns 10 (21.3) 2.11 (0.88–5.01) P = 0.092 ns
Allele carriage
 ≥1 232I allele 13 (68.4) 0.31 (0.11–0.87) P = 0.026 ns 37 (78.7) 0.52 (0.23–1.16) P = 0.110 ns
 ≥1 232T allele 12 (63.2) 1.67 (0.64–4.39) P = 0.298 ns 28 (59.6) 1.44 (0.76–2.71) P = 0.264 ns
FcγRIIIa (rs396991) P = 0.711 ns P = 0.145 ns
Genotype
 158F/FF/FF (ref) 9 (47.4) 1 22 (46.8) 1
 158FV/FFV/FVV 8 (42.1) 0.65 (0.24–1.75) P = 0.391 ns 23 (48.9) 0.76 (0.40–1.46) P = 0.410 ns
 158V/VV 2 (10.5) 0.62 (0.13–3.01) P = 0.550 ns 2 (4.3) 0.25 (0.06–1.14) P = 0.073 ns
Allele carriage
 ≥1 158F allele 17 (89.5) 0.64 (0.25–1.64) P = 0.354 ns 45 (95.7) 0.66 (0.35–1.23) P = 0.190 ns
 ≥1 158V allele 10 (52.6) 1.29 (0.28–5.87) P = 0.740 ns 25 (53.2) 3.42 (0.79–14.81) P = 0.100 ns
FcγRIIIb P = 0.182 ns P = 0.079 ns
Genotype
 HNA1a+/1b−/1c− 3 (15.8) 0.76 (0.17–3.29) P = 0.709 ns 7 (14.9) 0.63 (0.24–1.66) P = 0.350 ns
 HNA1a−/1b+/1c− 1 (5.3) 0.58 (0.07–5.24) P = 0.631 ns 6 (12.8) 1.25 (0.43–3.61) P = 0.678 ns
 HNA1a−/1b−/1c+ 1 (5.3) 1.04 (0.11–9.62) P = 0.970 ns 4 (8.5) 1.49 (0.43–5.20) P = 0.532 ns
 HNA1a+/1b+/1c− (ref) 5 (26.3) 1 14 (29.8) 1
 HNA1a+/1b−/1c+ 2 (10.5) 0.81 (0.15–4.39) P = 0.808 ns 4 (8.5) 0.58 (0.18–1.89) P = 0.365 ns
 HNA1a−/1b+/1c+ 5 (26.3) 3.32 (0.88–12.52) P = 0.077 ns 6 (12.8) 1.42 (0.49–4.14) P = 0.518 ns
 HNA1a+/1b+/1c+ 2 (10.5) 4.17 (0.68–25.59) P = 0.123 ns 6 (12.8) 4.47 (1.30–15.31) P = 0.017 ns
Allele carriage
 ≥1 HNA1a allotype 12 (63.2) 0.60 (0.23–1.60) P = 0.307 ns 31 (66.0) 0.70 (0.35–1.33) P = 0.258 ns
 ≥1 HNA1b allotype 13 (68.4) 1.84 (0.68–5.01) P = 0.231 ns 32 (68.1) 1.81 (0.93–3.53) P = 0.079 ns
 ≥1 HNA1c allotype 10 (52.6) 2.19 (0.86–5.62) P = 0.101 ns 20 (42.6) 1.46 (0.77–2.77) P = 0.243 ns

P values less than 0.05 are indicated in italics

P Bonf Bonferroni corrected P value, OR odds ratio, CI confidence interval, ns not statistically significant, –, the variable of interest was not detected in any of the cases and thus could not be analysed