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. 2016 Jun 10;13:40. doi: 10.1186/s12977-016-0272-y

Table 5.

Infant FcγR variants associated with perinatal HIV-1 acquisition after adjusting for confounding variables

Total infected Intrapartum infected
Univariate Adjusted for VLa PBonf Univariate Adjusted for VL PBonf
AOR (95 % CI) P value AOR (95 % CI) P value
FcγRIIa (rs1801274)
Genotype
 131HH (ref) 1 1
 131HR P = 0.426 0.79 (0.38–1.62) P = 0.519 ns P = 0.670 0.80 (0.27–2.32) P = 0.685 ns
 131RR P = 0.516 0.84 (0.39–1.83) P = 0.657 ns P = 0.895 0.97 (0.31–2.97) P = 0.951 ns
Allele carriage
 ≥1 131H allele P = 0.848 1.01 (0.55–1.85) P = 0.970 ns P = 0.854 0.89 (0.37–2.12) P = 0.792 ns
 ≥1 131R allele P = 0.414 0.81 (0.41–1.59) P = 0.536 ns P = 0.737 0.87 (0.32–2.32) P = 0.774 ns
FcγRIIb (rs1050501)
Genotype
 232II (ref) 1 1
 232IT P = 0.583 1.29 (0.70–2.39) P = 0.415 ns P = 0.811 1.40 (0.57–3.44) P = 0.469 ns
 232TT P = 0.110 1.97 (0.89–4.37) P = 0.096 ns P = 0.525 1.82 (0.56–5.90) P = 0.317 ns
Allele carriage
 ≥1 232I allele P = 0.132 0.57 (0.28–1.20) P = 0.140 ns P = 0.554 0.65 (0.22–1.90) P = 0.429 ns
 ≥1 232T allele P = 0.280 1.46 (0.83–2.57) P = 0.195 ns P = 0.660 1.50 (0.65–3.47) P = 0.344 ns
FcγRIIIa (rs396991)
Genotype
 158F/FF/FF (ref) 1 1
 158FV/FFV/FVV P = 0.456 0.87 (0.49–1.56) P = 0.647 ns P = 0.821 1.14 (0.49–2.66) P = 0.764 ns
 158V/VV P = 0.145 0.28 (0.08–1.00) P = 0.051 ns P = 0.899 0.28 (0.03–2.27) P = 0.232 ns
Allele carriage
 ≥1 158F allele P = 0.272 3.34 (0.96–11.57) P = 0.058 ns P = 0.819 3.89 (0.50–30.31) P = 0.194 ns
 ≥1 158V allele P = 0.198 0.75 (0.43–1.31) P = 0.311 ns P = 0.964 0.95 (0.42–2.19) P = 0.910 ns
FcγRIIIb
Genotype
 HNA1a+/1b−/1c− P = 0.040 0.37 (0.15–0.92) P = 0.033 ns P = 0.035 0.20 (0.04–0.96) P = 0.044 ns
 HNA1a−/1b+/1c− P = 0.565 0.69 (0.25–1.86) P = 0.459 ns P = 0.160 0.20 (0.03–1.69) P = 0.139 ns
 HNA1a−/1b−/1c+ P = 0.672 0.70 (0.18–2.78) P = 0.616 ns – – P = 0.970
 HNA1a+/1b+/1c− (ref) 1 1
 HNA1a+/1b−/1c+ P = 0.643 0.73 (0.31–1.72) P = 0.478 ns P = 0.863 0.97 (0.33–2.79) P = 0.949 ns
 HNA1a−/1b+/1c+ P = 0.260 1.57 (0.64–3.88) P = 0.326 ns P = 0.272 1.80 (0.57–5.71) P = 0.316 ns
 HNA1a+/1b+/1c+ P = 0.086 2.36 (0.63–8.75) P = 0.201 ns P = 0.843 – ns P = 0.123
Allele carriage
 ≥1 HNA1a allotype P = 0.408 0.79 (0.43–1.46) P = 0.452 ns P = 0.986 1.01 (0.40–2.56) P = 0.981 ns
 ≥1 HNA1b allotype P = 0.020 2.02 (1.12–3.64) P = 0.019 ns P = 0.079 1.91 (0.81–4.53) P = 0.140 ns
 ≥1 HNA1c allotype P = 0.075 1.52 (0.86–2.69) P = 0.146 ns P = 0.110 1.74 (0.77–3.96) P = 0.185 ns
In utero infected In utero-enriched infected
Univariate Adjusted for VL + bwt PBonf Univariate Adjusted for VL PBonf
AOR (95 % CI) P value AOR (95 % CI) P value
FcγRIIa (rs1801274)
Genotype
 131HH (ref) 1 1
 131HR P = 0.456 0.71 (0.15–3.25) P = 0.657 ns P = 0.455 0.75 (0.32–1.79) P = 0.520 ns
 131RR P = 0.541 1.87 (0.45–7.79) P = 0.390 ns P = 0.433 0.77 (0.30–1.96) P = 0.581 ns
Allele carriage
 ≥1 131H allele P = 0.139 0.42 (0.15–1.21) P = 0.108 ns P = 0.685 1.07 (0.51–2.22) P = 0.858 ns
 ≥1 131R allele P = 0.912 1.17 (0.31–4.58) P = 0.817 ns P = 0.396 0.76 (0.34–1.70) P = 0.503 ns
FcγRIIb (rs1050501)
Genotype
 232II (ref) 1 1
 232IT P = 0.862 0.80 (0.23–2.74) P = 0.724 ns P = 0.577 1.18 (0.56–2.50) P = 0.658 ns
 232TT P = 0.038 3.53 (0.95–13.14) P = 0.060 ns P = 0.092 2.02 (079–5.16) P = 0.144 ns
Allele carriage
 ≥1 232I allele P = 0.026 0.26 (0.08–0.86) P = 0.028 ns P = 0.110 0.54 (0.23–1.28) P = 0.160 ns
 ≥1 232T allele P = 0.298 1.33 (0.47–3.77) P = 0.593 ns P = 0.264 1.38 (0.70–2.74) P = 0.353 ns
FcγRIIIa (rs396991)
Genotype
 158F/FF/FF (ref) 1 1
 158FV/FFV/FVV P = 0.391 0.61 (0.20–1.86) P = 0.385 ns P = 0.410 0.74 (0.37–1.49) P = 0.405 ns
 158V/VV P = 0.550 0.85 (0.16–4.42) P = 0.842 ns P = 0.073 0.29 (0.06–1.36) P = 0.117 ns
Allele carriage
 ≥1 158F allele P = 0.354 0.93 (0.19–4.53) P = 0.931 ns P = 0.190 2.91 (0.66–12.92) P = 0.160 ns
 ≥1 158V allele P = 0.740 0.66 (0.23–1.85) P = 0.425 ns P = 0.100 0.65 (0.33–1.28) P = 0.215 ns
FcγRIIIb
Genotype
 HNA1a+/1b−/1c− P = 0.709 0.77 (0.15–3.86) P = 0.748 ns P = 0.350 0.53 (0.18–1.52) P = 0.234 ns
 HNA1a−/1b+/1c− P = 0.631 0.46 (0.04–4.76) P = 0.513 ns P = 0.678 1.13 (0.37–3.42) P = 0.827 ns
 HNA1a−/1b−/1c+ P = 0.970 1.48 (0.14–15.83) P = 0.744 ns P = 0.532 1.33 (0.32–5.54) P = 0.695 ns
 HNA1a+/1b+/1c− (ref) 1 1
 HNA1a+/1b−/1c+ P = 0.808 0.65 (0.10–4.10) P = 0.645 ns P = 0.365 0.50 (0.15–1.67) P = 0.259 ns
 HNA1a−/1b+/1c+ P = 0.077 4.47 (0.84–23.80) P = 0.080 ns P = 0.518 1.50 (0.46–4.92) P = 0.501 ns
 HNA1a+/1b+/1c+ P = 0.123 3.35 (0.40–27.73) P = 0.262 ns P = 0.017 4.44 (1.14–17.40) P = 0.032 ns
Allele carriage
 ≥1 HNA1a allotype P = 0.307 0.58 (0.19–1.76) P = 0.337 ns P = 0.258 0.66 (0.32–1.37) P = 0.265 ns
 ≥1 HNA1b allotype P = 0.231 1.82 (0.63–5.32) P = 0.271 ns P = 0.079 2.16 (1.05–4.44) P = 0.037 ns
 ≥1 HNA1c allotype P = 0.101 2.16 (0.76–6.14) P = 0.149 ns P = 0.243 1.42 (0.71–2.81) P = 0.321 ns

P values less than 0.05 are indicated in italics

P Bonf Bonferroni corrected P value, AOR adjusted odds ratio, CI confidence interval, VL viral load, bwt birth weight, –, the variable of interest was not detected in any of the cases and thus could not be analysed

aThe multivariate analysis adjusted for demographic and clinical variables that independently associated with transmission. Due to high correlation with viral load, CD4 T cell counts were not included in the multivariate model