Fig. 5.

Reductive tricarboxylic acid cycle in M. maripaludis with associated ORFs. The solid lines show the presence of enzymes in M. maripaludis and dotted lines show their absence. The enzymes corresponding to the various reaction numbers are: 16. pyruvate carboxylase (6.4.1.1, pycB); 17. malate dehydrogenase (1.1.1.37, mdh) 18. fumarate hydratase (4.2.1.2, fumA); 19. succinate dehydrogenase/fumarate reductase (1.3.5.4/1.3.4.1, sdhA); 20. succinyl-CoA synthetase (6.2.1.5, sucC & sucD); 21. 2-oxoglutarate oxidoreductase (1.2.7.3, korABDG); 22. citrate synthase; 23. aconitate; 24. isocitrate dehydrogenase