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. 2016 Jun 10;35:91. doi: 10.1186/s13046-016-0369-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Matrigel plug assay and the correlation between MUC4/Y-AMOP domain and mouse survival. a Cells were suspended in Matrigel and DMEM and subcutaneously into the flanks of mice (n = 8). After 15 days, the Matrigel plugs were removed and photographed. Representative Matrigel plugs from the PANC-EV, PANC-MUC4/Y, and PANC-MUC4/Y-AMOP^△groups are shown. b The relative amount of angiogenesis was analysed based on the RBC haemoglobin level, determined using the Drabkin method. The relative haemoglobin content is the haemoglobin level (mg) divided by the final volume of each plug. c CD31 immunohistochemistry was performed on the Matrigel plugs from the PANC-EV, PANC-MUC4/Y, and PANC-MUC4/Y-AMOP^△groups. d Microvessel density of CD31 immunohistochemistry. Each slide was evaluated with five fields, and the data were analysed as the mean vessel number of these five fields. e Kaplan-Meier survival curves in 45 mice with PANC-1 derived sub-lines orthotopically implanted. The p values were calculated by the log-rank test (Table 1)