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. 2016 Jun 10;18:135. doi: 10.1186/s13075-016-1020-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Decision tree for the first year comparing the current diagnostic test strategy with the new diagnostic add-on test strategy for intermediate-risk patients. Current test strategy American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2010 rheumatoid arthritis (RA) classification criteria. New test strategy add-on test for intermediate-risk patients (3–5 points) according to the ACR/EULAR 2010 RA classification criteria. IA inflammatory arthritis, MTX methotrexate, TP true positive, FP false positive, TN true negative, FN false negative, T0 baseline, T6 6 months, T12 12 months. b Patient-level transition state model and background model of second to fifth year for all test strategies. DAS28 disease activity score in 28 joints