Table 1.

Reclassification table with the results for intermediate-risk patients according to the ACR/EULAR 2010 RA classification criteria and for all patients

	Number of patients according to ACR/EULAR 2010 RA classification criteria	Number of patients reclassified as high risk	Number of patients reclassified as low risk	Combined sensitivity: RA-2010 criteria + new test	Combined specificity: RA-2010 criteria + new test
(A) Add-on test for all patients
B cell test				0.85	0.69
High risk	243	243	0
Intermediate risk	263	75 (29 %)	188 (71 %)
Low risk	46	13 (28 %)	33 (72 %)
IL-6 test				0.89	0.41
High risk	243	243	0
Intermediate risk	263	146 (56 %)	117 (44 %)
Low risk	46	26 (57 %)	20 (43 %)
Magnetic resonance imaging				0.96	0.46
High risk	243	243	0
Intermediate risk	263	154 (59 %)	109 (41 %)
Low risk	46	26 (59 %)	20 (41 %)
Genetic assay test				0.77	0.66
High risk	243	243	0
Intermediate risk	263	64 (24 %)	199 (76 %)
Low risk	46	11 (24 %)	35 (76 %)
(B) Add-on test for intermediate-risk patients
B cell test				0.81	0.71
High-risk	243	243	0
Intermediate risk	263	75 (29 %)	188 (71 %)
Low risk	46	0	46
IL-6 test				0.85	0.46
High risk	243	243	0
Intermediate risk	263	146 (56 %)	117 (44 %)
Low risk	46	0	46
MRI				0.91	0.51
High risk	243	243	0
Intermediate risk	263	154 (59 %)	109 (41 %)
Low risk	46	0	46
Genetic assay test				0.75	0.67
High risk	243	243	0
Intermediate risk	263	64 (24 %)	199 (76 %)
Low risk	46	0	46

Combined sensitivity = sensitivity of American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2010 rheumatoid arthritis (RA) classification criteria + sensitivity of the new test. Combined specificity = specificity of ACR/EULAR 2010 RA classification criteria + specificity of the new test.