Table 1.

Effects of melatonin on ovary transplantation

Author	Species	Study model	Melatonin route and dosage	Results of melatonin use
Friedman, 2012 [3]	Human; Nu/nu Balb/c mice	Xenotransplanted thawed graft; donor: 5 cancer patients aged 6–23 years; recipient: 79 immunodeficient nu/nu Balb/c mice aged 10–12 weeks	Oral administration in feeding water; 240 mg/L	Reduced number of apoptosis and atretic follicles
Hemadi, 2012 [19]	Balb/c mice	Heterologous thawed graft; donor: mice aged 10 days; recipient: 180 mice aged 8–10 weeks; 900 transplants	Oral administration; 20–200 mg/kg/day	Enhanced follicle quality, quantity, and graft size with low dosage; diminished Th1/Th2 immunological reaction and longer graft lifespan with high dosage
Hemadi, 2011 [18]	F1 hybrid mice	Heterologous thawed graft; donor: mice aged 10 days; recipient: 60 mice aged 8–10 weeks	Graft: 100 μM PBF Recipient: intraperitoneal for 2 days; 20 mg/kg/day	Enhanced corpora lutea, secondary and antral follicles
Hemadi, 2009 [17]	F1 hybrid mice	Heterologous thawed graft; donor: 120 mice aged 10 days; recipient: 36 mice aged 8–10 weeks	Graft: 100 μM PBF Recipient: intraperitoneal for 2 days; 20 mg/kg/day	Improved mean graft survival, ovary size, and revascularization
Sapmaz, 2003 [14]	Wistar albino rats	Autologous fresh graft; 28 Wistar albino rats aged 12–14 weeks	intraperitoneal prior to transplantation; 20 mg/kg	Diminished ovarian and plasmatic malondialdehyde and ovarian necrosis; enhanced glutathione peroxidase and superoxide dismutase