Skip to main content
. 2015 Dec 17;42(4):1009–1017. doi: 10.1093/schbul/sbv184

Fig. 3.

Fig. 3.

The association between peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and Parvalbumin (PV) expression is influenced by nuclear respiratory factor 1 (NRF-1) levels. PV expression data are displayed for controls (A) and patients with schizophrenia (B), with respect to PGC-1α and NRF-1 expression. The positive relationship between the expression of PGC-1α and its targets is no longer evident when NRF-1 expression is low. Rats treated for 36 weeks with haldol showed no difference in transcript for PGC-1α, its putative targets, or NRF-1 compared to rats treated with sesame oil (n = 10/group; C; mean ± SEM). We propose that a reduction in NRF-1 could contribute to a decrease in the expression of PGC-1α-dependent genes in schizophrenia (D).