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. Author manuscript; available in PMC: 2016 Jun 11.
Published in final edited form as: Dev Biol. 2013 Sep 11;383(1):15–27. doi: 10.1016/j.ydbio.2013.09.005

Fig. 6.

Fig. 6

CTR9 deficiency results in global reduction of H3K36me3 in vivo. H3K36me3 is severely reduced in dsCtr9 morula (A) and blastocysts (B) (9 control and 10 dsCtr9 morula; 9 control and 13 dsCtr9 blastocysts were analyzed). Scale bar: 50 μm. (C–D) Normal level and distribution of H3K4me3 and H3K9me3 were observed in dsCtr9 embryos at all stages examined. Scale bar: 50 μm. Knock down of Setd2 (that mediates H3K36me3) similarly compromised blastocyst outgrowth potential (E), outgrowth area (F), as well as the number of trophoblast giant cells observed (G). Scale bar in E is 20 μm. Asterisks indicate P<0.05. Error bars represent SEM.