Table 5c.
Association between internal dose of THMs (within the fourth quartile in comparison to the first three quartiles) and SGA for newborns and mothers GSTT1 or GSTM1 deletion status
| Gene/deletion | Cases | Controls | CHCL3a | THMBra | TTHMa | |||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| n | n | Adjusted ORb (95% CI) | p interaction | Adjusted ORb (95% CI) | p interaction | Adjusted ORb (95% CI) | p interaction | |
|
|
||||||||
| Newborns | ||||||||
| GSTT1 | ||||||||
| No or single deletion | 198 | 793 | 1.1 (0.7 – 1.7) | 0.61 | 0.9 (0.6 – 1.4) | 0.86 | 1.1 (0.7 – 1.6) | 0.44 |
| Double deletion | 73 | 300 | 1.4 (0.7 – 2.7) | 1.0 (0.5 – 2.0) | 1.4 (0.7 – 2.7) | |||
| GSTM1 | ||||||||
| No or single deletion | 112 | 491 | 1.4 (0.8 – 2.4) | 0.96 | 1.1 (0.6 – 1.8) | 0.67 | 1.4 (0.8 – 2.4) | 0.95 |
| Double deletion | 159 | 602 | 1.4 (0.7 – 2.8) | 1.2 (0.6 – 2.4) | 1.4 (0.7 – 2.8) | |||
| Mothers | ||||||||
| GSTT1 | ||||||||
| No or single deletion | 59 | 228 | 1.1 (0.7 – 1.7) | 0.48 | 0.9 (0.6 – 1.4) | 0.65 | 1.1 (0.7 – 1.4) | 0.18 |
| Double deletion | 212 | 865 | 1.5 (0.7 – 3.2) | 1.1 (0.5 – 2.3) | 1.8 (0.9 – 2.3) | |||
| GSTM1 | ||||||||
| No or single deletion | 146 | 610 | 1.4 (0.8 – 2.4) | 0.67 | 1.1 (0.6 – 1.8) | 0.38 | 1.4 (0.8 – 1.8) | 0.64 |
| Double deletion | 125 | 483 | 1.2 (0.6 – 2.4) | 0.8 (0.4 – 1.6) | 1.2 (0.6 – 1.6) | |||
a
CHCl3=Chloroform, THMBr= Brominated THM, TTHM= Total Trihalomethanes
b
OR adjusted for the following variables: maternal age, maternal education, annual household income, prepregnancy BMI, parity, history of chronic disease, preeclampsia, active smoking during the third trimester, passive smoking throughout pregnancy, coffee and alcohol consumption during pregnancy and month of selection.