. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Environ Int. 2016 Apr 22;92-93:220–231. doi: 10.1016/j.envint.2016.03.033

Table 5d.

Association between internal dose of HAAs (within the fourth quartile in comparison to the first three quartiles) and SGA for newborns and mothers GSTT1 or GSTM1 deletion status

Gene/deletion	Cases	Controls	DCAA^a		TCAA^a		HAA5^a		HAA9^a

	n	n	Adjusted OR^b (95% CI)	p interaction	Adjusted OR^b (95% CI)	p interaction	Adjusted OR^b (95% CI)	p interaction	Adjusted OR^b (95% CI)	p interaction

Newborns
*GSTT1*
No or single deletion	198	793	1.6 (1.1 – 2.3)	0.35	1.7 (1.1 – 2.5)	0.40	1.7 (1.1 – 2.5)	0.41	1.7 (1.2 – 2.5)	0.95
Double deletion	73	300	2.2 (1.2 – 4.1)		2.3 (1.2 – 4.3)		2.2 (1.2 – 4.2)		1.7 (0.9 – 3.3)
*GSTM1*
No or single deletion	112	491	1.6 (1.0 – 2.6)	0.91	1.9 (1.1 – 3.1)	0.84	1.5 (0.9 – 2.5)	0.88	1.5 (0.9 – 2.5)	0.42
Double deletion	159	602	1.5 (0.8 – 3.0)		1.8 (0.9 – 3.4)		1.6 (0.8 – 3.0)		2.0 (1.0 – 3.9)
Mothers
*GSTT1*
No or single deletion	212	865	1.6 (1.1 – 2.3)	0.26	1.7 (1.1 – 2.5)	0.14	1.7 (1.1 – 2.5)	0.061	1.7 (1.2 – 2.5)	0.27
Double deletion	59	228	1.0 (0.5 – 2.1)		0.9 (0.4 – 2.0)		0.8 (0.4 – 2.0)		1.1 (0.5 – 2.3)
*GSTM1*
No or single deletion	125	483	1.6 (1.0 – 2.6)	0.95	1.9 (1.1 – 3.1)	0.50	1.5 (0.9 – 3.1)	0.94	1.5 (0.9 – 2.5)	0.51
Double deletion	146	610	1.6 (0.8 – 3.3)		1.5 (0.7 – 3.0)		1.5 (0.8 –3.0)		1.2 (0.6 – 2.4)

DCAA=Dichloracetic acid, TCAA=Trichloroacetic acid, HAA(5)=sum of the main five HAA species (DCAA, TCAA, monochloracetic acid, monobromacetic acid, dibromoacetic acid), HAA(9) =sum of all HAA species.

OR adjusted for the following variables: maternal age, maternal education, annual household income, prepregnancy BMI, parity, history of chronic disease, preeclampsia, active smoking during the third trimester, passive smoking throughout pregnancy, coffee and alcohol consumption during pregnancy and month of selection.