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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Environ Int. 2016 Apr 22;92-93:220–231. doi: 10.1016/j.envint.2016.03.033

Table 4b.

Association between exposure to HAAs concentration (within the fourth quartile in comparison to the first three quartiles) and SGA for newborns and mothers carriers of CYP2E1 SNP genotypes of wild type or with 1 or 2 variant alleles

CYP2E1/SNPs Cases Controls DCAAa TCAAa HAA5a HAA9a
n n Adjusted ORb (95% CI) p interaction Adjusted ORb (95% CI) p interaction Adjusted ORb (95% CI) p interaction Adjusted ORb (95% CI) p interaction
Newborns
rs3813867
 Wild type 275 1071 1.3 (0.9 – 1.7) 0.38 1.4 (1.0 – 1.9) 0.14 1.4 (1.0 – 2.0) 0.15 1.5 (1.1 – 2.0) 0.16
 1 or 2 var.alc 15 66 2.5 (0.6 – 11.2) 4.5 (1.0 – 20.7) 4.5 (1.0 –20.8) 4.5 (1.0 – 21.0)
rs2031920
 Wild type 267 1042 1.2 (0.9 – 1.7) 0.30 1.3 (1.0 – 1.9) 0.16 1.4 (1.0 – 1.9) 0.17 1.4 (1.0 – 2.0) 0.18
 1 or 2 var.al 17 65 2.7 (0.6 – 11.9) 3.9 (0.9 – 17.2) 3.9 (0.9 –17.3) 3.9 (0.9 –17.4)
rs117618383
 Wild type 258 1061 1.1 (0.8 – 1.6) 0.03d 1.4 (1.0 – 1.9) 0.10d 1.4 (1.0 – 1.9) 0.04d 1.4 (1.0 – 1.9) 0.03d
 1 or 2 var.al 27 77 4.9 (1.3 – 17.9) 3.9 (1.1 – 13.5) 5.3 (1.5 –18.6) 5.8 (1.6 –20.7)
rs2515641
 Wild type 210 905 1.2 (0.8 – 1.7) 0.96d 1.3 (0.9 – 1.9) 0.63d 1.5 (1.0 – 2.2) 0.81d 1.5 (1.1 – 2.2) 0.84d
 1 or 2 var.al 71 231 1.2 (0.6 – 2.6) 1.6 (0.8 – 3.4) 1.4 (0.7 – 2.9) 1.4 (0.7 – 3.0)
Mothers
rs3813867
 Wild type 273 1061 1.3 (0.9 – 1.7) 0.19 1.4 (1.0 – 1.9) 0.06 1.4 (1.0 – 1.9) 0.05 1.5 (1.1 – 2.0) 0.051
 1 or 2 var.al 17 76 0.5 (0.1 – 2.0) 0.3 (0.1 – 1.5) 0.3 (0.1 – 1.5) 0.3 (0.1 – 1.5)
rs2031920
 Wild type 267 1034 1.2 (0.9 – 1.7) 0.15 1.3 (1.0 – 1.9) 0.06 1.4 (1.0 – 1.9) 0.06 1.4 (1.0 – 2.0) 0.057
 1 or 2 var.al 17 73 0.4 (0.1 – 1.9) 0.3 (0.1 – 1.4) 0.3 (0.1 – 1.4) 0.3 (0.1 – 1.5)
rs117618383
 Wild type 262 1054 1.1 (0.8 – 1.6) 0.84d 1.4 (1.0 – 1.9) 0.95d 1.4 (1.0 – 1.9) 0.77d 1.4 (1.0 – 1.9) 0.70d
 1 or 2 var.al 23 84 1.0 (0.2 – 3.9) 1.3 (0.4 – 4.8) 1.1 (0.3 – 4.8) 1.0 (0.3 – 4.1)
rs2515641
 Wild type 216 910 1.2 (0.8 – 1.7) 0.40d 1.3 (0.9 – 1.9) 0.48d 1.5 (1.0 – 1.9) 0.69d 1.5 (1.1 – 2.2) 0.77d
 1 or 2 var.al 65 226 1.6 (0.8 – 3.5) 1.7 (0.8 – 3.6) 1.7 (0.8 – 3.6) 1.7 (0.8 – 3.6)
a

DCAA=Dichloracetic acid, TCAA=Trichloroacetic acid, HAA(5)=sum of the main five HAA species (DCAA, TCAA, monochloracetic acid, monobromacetic acid, dibromoacetic acid), HAA(9) =sum of all HAA species.

b

OR adjusted for the following variables: maternal age, maternal education, annual household income, prepregnancy BMI, parity, history of chronic disease, preeclampsia, active smoking during the third trimester, passive smoking throughout pregnancy, coffee and alcohol consumption during pregnancy and month of selection.

c

1 or var. al = 1 or 2 variant alleles.

d

The Bonferroni corrected significance level of 0.005 applies to these interaction tests.