Table 4c.
Association between internal dose of THMs (within the fourth quartile in comparison to the first three quartiles) and SGA for newborns and mothers carriers of CYP2E1 SNP genotypes of wild type or 1 or 2 variant alleles
| CYP2E1/SNPs | Cases | Controls | CHCL3a | THMBra | TTHMa | |||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| n | n | Adjusted ORb (95% CI) | p interaction | Adjusted ORb (95% CI) | p interaction | Adjusted ORb (95% CI) | p interaction | |
|
|
||||||||
| Newborns | ||||||||
| rs3813867 | ||||||||
| Wild type | 275 | 1071 | 1.2 (0.9 – 1.7) | 0.69 | 1.1 (0.8 – 1.6) | 0.27 | 1.2 (0.9 – 1.7) | 0.52 |
| 1 or 2 var.alc | 15 | 66 | 1.7 (0.3 – 8.7) | 0.3 (0.0 – 3.2) | 2.1 (0.4 – 11.2) | |||
| rs2031920 | ||||||||
| Wild type | 267 | 1042 | 1.1 (0.8 – 1.6) | 0.47 | 1.1 (0.8 – 1.6) | 0.19 | 1.2 (0.9 – 1.7) | 0.52 |
| 1 or 2 var.al | 17 | 65 | 2.0 (0.4 – 9.8) | 0.2 (0.0 – 2.5) | 2.1 (0.4 – 10) | |||
| rs117618383 | ||||||||
| Wild type | 258 | 1061 | 1.1 (0.8 – 1.6) | 0.09d | 1.2 (0.8 – 1.6) | 0.04d | 1.1 (0.8 – 1.5) | 0.14d |
| 1 or 2 var.al | 27 | 77 | 3.4 (0.9 – 11.9) | 0.2 (0.0 – 1.1) | 2.8 (0.8 – 9.6) | |||
| rs2515641 | ||||||||
| Wild type | 210 | 905 | 1.2 (0.8 – 1.7) | 0.29d | 1.0 (0.7 – 1.5) | 0.12d | 1.2 (0.8 – 1.7) | 0.22d |
| 1 or 2 var.al | 71 | 231 | 1.8 (0.8 – 4.0) | 1.9 (0.9 – 4.3) | 1.9 (0.9 – 4.2) | |||
| Mothers | ||||||||
| rs3813867 | ||||||||
| Wild type | 273 | 1061 | 1.2 (0.9 – 1.7) | 0.16 | 1.1 (0.8 – 1.6) | 0.53 | 1.2 (0.9 – 1.6) | 0.13 |
| 1 or 2 var.al | 17 | 76 | 0.3 (0.1 – 2.0) | 0.7 (0.1 – 3.4) | 0.3 (0.1 – 3.4) | |||
| rs2031920 | ||||||||
| Wild type | 267 | 1034 | 1.1 (0.8 – 1.6) | 0.14 | 1.1 (0.8 – 1.6) | 0.66 | 1.2 (0.9 – 1.6) | 0.13 |
| 1 or 2 var.al | 17 | 73 | 0.3 (0.0 – 1.8) | 0.8 (0.1 – 4.0) | 0.3 (0.0 – 4.0) | |||
| rs117618383 | ||||||||
| Wild type | 262 | 1054 | 1.1 (0.8 – 1.6) | 0.67d | 1.2 (0.8 – 1.6) | 0.71d | 1.1 (0.8 – 1.6) | 0.97d |
| 1 or 2 var.al | 23 | 84 | 0.8 (0.2 – 3.2) | 0.9 (0.2 – 3.6) | 1.1 (0.3 – 3.6) | |||
| rs2515641 | ||||||||
| Wild type | 216 | 910 | 1.2 (0.8 – 1.7) | 0.39d | 1.0 (0.7 – 1.5) | 0.10d | 1.2 (0.8 – 1.5) | 0.20d |
| 1 or 2 var.al | 65 | 226 | 0.8 (0.4 – 1.8) | 0.5 (0.2 – 1.2) | 0.8 (0.4 – 1.2) | |||
a
CHCl3=Chloroform, THMBr= Brominated THM, TTHM= Total Trihalomethanes
b
OR adjusted for the following variables: maternal age, maternal education, annual household income, prepregnancy BMI, parity, history of chronic disease, preeclampsia, active smoking during the third trimester, passive smoking throughout pregnancy, coffee and alcohol consumption during pregnancy and month of selection.
c
1 or var. al = 1 or 2 variant alleles.
d
The Bonferroni corrected significance level of 0.005 applies to these interaction tests.