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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Exp Neurol. 2015 Dec 11;285(Pt B):126–135. doi: 10.1016/j.expneurol.2015.12.006

Figure 5. BDNF-induced CREB activity was mediated by TrkB and PLCγ.

Figure 5

BDNF stimulation of cultured DRG explants for 5 or 10 min (n=5) resulted in an increase in CREB phosphorylation (A and B). Treatment of DRG explants with TrkB inhibitor K252a (C and D) blocked BDNF-elicited CREB phosphorylation (n=3). Treatment of DRG explants with PLCγ inhibitor U73122 (C and D) also blocked BDNF-elicited CREB phosphorylation (n=3). The inhibition experiments were done with BDNF treatment for 5 min. Segment-matched DRG explants were used as comparison. *, p<0.05 vs control. #, p<0.05 vs BDNF treatment.