Table 3.

Regions (and x, y, and z coordinates) associated with reduced activation in type 2 diabetes.

All (22 pairs)
Region	Hemisphere	x	y	z	Z score	k
Middle temporal gyrus	L	−48	−66	20	4.64	401
Angular gyrus	L	−36	−66	34	3.36
Angular gyrus	L	−40	−68	36	3.35
Middle temporal gyrus	L	−48	−64	32	3.29
Inferior parietal lobule	L	−50	−46	26	3.22
Middle temporal gyrus	L	−46	−72	30	3.08
Middle temporal gyrus	L	−52	−36	−8	4.39	399
Middle temporal gyrus	L	−62	−46	−8	4.26
Middle temporal gyrus	L	−62	−36	−12	3.43
Middle temporal gyrus	L	−64	−34	−16	3.41
Middle temporal gyrus	L	−56	−40	4	3.32
Superior temporal gyrus	L	−62	−44	6	3.3
MZ (8 pairs)
Region	Hemisphere	x	y	z	Z score	k
Medial frontal gyrus	L	−10	58	4	4.29	270
Medial frontal gyrus	L	−6	48	18	4.27
Superior frontal gyrus	L	−12	62	8	4.2
Medial frontal gyrus	L	−6	48	14	4.16
Medial frontal gyrus	L	−6	54	20	4.12
DZ (14 pairs)
Region	Hemisphere	x	y	z	Z score	k
Middle temporal gyrus	L	−60	−48	−10	3.71	421
Middle temporal gyrus	L	−52	−36	−10	3.5
Middle temporal gyrus	L	−54	−46	8	3.42
Middle temporal gyrus	L	−56	−36	−8	3.32
Middle temporal gyrus	L	−60	−32	−10	3.3
Middle temporal gyrus	L	−64	−34	−16	3.09
Middle temporal gyrus	L	−48	−66	22	3.8	307
Angular gyrus	L	−38	−66	34	3.38
Middle temporal gyrus	L	−38	−68	30	3.34
Supramarginal gyrus	L	−46	−52	34	3.1
Middle temporal gyrus	L	−42	−68	30	3.04
Middle temporal gyrus	L	−46	−72	30	3.02

Covariates include gender (except in MZ comparisons), waist circumference, and history of hypertension.

MZ: monozygotic; DZ: dizygotic.

x, y, and z refer to Montreal Neurological Institute voxel coordinates; regions are based on the Talairach Daemon; k: peak voxel cluster; L: left hemisphere.

All comparisons are within twin pairs and corrected for family-wise error (FWE) threshold of 0.05.