QOS-33: PREVALENCE OF SLEEP DISORDERS IN CHILDREN WITH BRAIN TUMORS

INTRODUCTION: The prevalence of sleep disorders (SD) in children with brain tumors is unknown. Only few studies have been published regarding sleep disorders in this subset of patients. The main aim of this study is to compare the prevalence of SD between children treated for brain tumors and healthy children. MATERIALS AND METHODS: A retrospective case-control study was performed from January 2014 to January 2015. “Cases” included patients 2 to16 years old with a diagnosis of brain tumor, at least 3 months after the end of the treatment (surgery and/or radiotherapy and/or chemotherapy). “Controls” were healthy children 2 to 16 years old. Children's sleep quality was assessed with Child's Sleep Habits Questionnaire (CSHQ) administered to parents. Sleep was considered disturbed if at least one of the following events was present: sleep delay, sleep duration, sleep-related anxiety, night wakings, parasomnias and respiratory disorders. The risk of SD was estimated by Odds Ratio (OR) and 95% confidence intervals (95% CI) by multivariate logistic regression analysis. RESULTS: We enrolled 116 subjects, 29 cases and 87 controls. The prevalence of SD was 51,7% among cases, 33,5% in controls. The difference didn't reach statistical significance (OR= 2,14 CI: 0.91-5,03). Parasomnias and night wakings, when analyzed as single sleep disorders, showed a statistically significant difference (OR 4,32 IC95%: 1,08-17,34). CONCLUSION: The study showed a trend toward higher prevalence of SD in children with brain tumors. Parasomnias and night wakings were significantly more frequent in this group. Polysomnography and melatonin dosages could help to better characterize SD.