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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Autoimmun. 2016 Apr 5;71:88–96. doi: 10.1016/j.jaut.2016.03.008

Fig. 3.

Fig. 3

Standardized sample collection and mechanistic assay scheme to identify Immunologic surrogates of efficacy in T1D trials. Trials in new-onset T1D conducted by the Immune Tolerance Network (ITN) employ standardized sample collections (blue boxes: PBMCs, whole blood DNA, serum, and whole blood RNA), which are then analyzed by standardized assay procedures (green boxes: flow cytometry, in vitro T cell assays, epigenetic assays and genotyping, ELISAs and multiplex assays, and RNA-seq or NanoString analyses). Some of the expected outcomes of these assays are shown in the grey boxes.