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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Gene. 2016 May 4;589(1):1–11. doi: 10.1016/j.gene.2016.05.002

Table 2.

Function and regulation of JADE1 protein isoforms in epithelial cells and tissues.

G1/S G2/M Cytokinesis
JADE1 isoform JADE1L JADE1S ppJADE1L** ppJADE1S** JADE1L pJADE1S**
JADE1 subcellular localization Chromatin Chromatin Centrosome Cytoplasm Cytoplasm Centrosome Chromatin Cleavage furrow, Midbody
JADE1 activities Histone H4 bulk acetylation, homeostasis. DNA synthesis. Replication licensing(?*). Transcription(?*). JADE1S is phosphorylated by Aurora A pathway. Bulk of pJADE1** is removed from chromatin to allow chromosome condensation(?*). Specific fraction of pJADE1S** mediates NoCut in Aurora B pathway. Dephosphorylated JADE1S/L re-associates with relaxing chromatin
JADE1 dysregulation: predicted outcomes DNA damage, amplification, impaired tissue homeostasis, degeneration, or cancer Premature or delayed cytokinesis, cytokinesis failure with following aneuploidy, polyploidy, gene mutations, cell death or transformation. Impaired tissue homeostasis, degeneration, or cancer

The hypothetical scheme summarizes current literature about cellular activities of JADE1 protein isoform activities during the cell division.

*

predicted

**

phosphorylated form of JADE1 proteins