Table 1.
Descriptive characteristics of entire cohort, HCC group, and non-HCC group.
| Entire cohort (n = 178) | HCC (n = 63) | Non-HCC (n = 115) | HCC, bridged (n = 43) | HCC, non-bridged (n = 20) | TACE (n = 18) | Ablation (n = 25) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Liver transplant only | 169 (94.9%) | 59 (93.7) | 110 (95.7%) | p = 0.560 | 42 (97.7%) | 17 (85.0%) | p = 0.055 | 18 (100.0%) | 24 (96.0%) | p = 0.541 |
| Gender male | 123 (69.1%) | 43 (68.1%) | 80 (69.6%) | p = 0.856 | 31 (72.1%) | 12 (60.0%) | p = 0.337 | 13 (72.2%) | 18 (72.0%) | p = 0.888 |
| Age at transplant (mean) | 53.14 | 56.33 | 51.39 | p = 0.001 | 56.42 | 56.15 | p = 0.903 | 57.8 | 55.44 | p = 0.466 |
| Age at transplant (median) | 55 | 57 | 53 | p = 0.002 | 57 | 56 | p = 0.830 | 56.5 | 58 | p = 0.458 |
| Calculated MELD at transplant (mean) | 21.87 | 16.73 | 24.69 | p = 0.000 | 13.83 | 22.98 | p = 0.000 | 13.2 | 14.72 | p = 0.820 |
| Pre-transplant AFP | 20.09 | 40.84 | 7.55 | p = 0.020 | 55.59 | 8.24 | p = 0.225 | 39.99 | 67.29 | p = 0.607 |
| BMI (mean) | 29.8 | 30 | 29.75 | p = 0.795 | 29.8 | 30.44 | p = 0.677 | 29.6 | 29.93 | p = 0.864 |
| Etiology of cirrhosis | ||||||||||
| Hepatitis C virus | 73 (41%) | 42 (66.7%) | 31 (27%) | p = 0.000 | 28 (65.1%) | 14 (70.0%) | p = 0.702 | 10 (55.6%) | 18 (72.0%) | p = 0.001 |
| Hepatitis B virus | 7 (3.9%) | 6 (9.5%) | 1 (0.9%) | p = 0.005 | 5 (11.6%) | 1 (5.0%) | p = 0.404 | 2 (11.1%) | 3 (12.0%) | p = 0.012 |
| Alcoholic | 38 (21.3%) | 11 (17.5%) | 27 (23.5%) | p = 0.349 | 6 (14.0%) | 5 (25.0%) | p = 0.282 | 3 (16.7%) | 3 (12.0%) | p = 0.371 |
| Non-alcoholic steatohepatitis | 24 (13.5%) | 7 (11.1%) | 17 (14.8%) | p = 0.493 | 4 (9.3%) | 3 (15.0%) | p = 0.503 | 3 (16.7%) | 1 (4.0%) | p = 0.318 |
| Alpha-1 antitrypsin deficiency | 5 (2.8%) | 2 (3.2%) | 3 (2.6%) | p = 0.827 | 1 (2.3%) | 1 (5.0%) | p = 0.573 | 0 (0.0%) | 1 (4.0%) | p = 0.718 |
| Cryptogenic | 13 (7.3%) | 1 (1.6%) | 12 (10.4%) | p = 0.030 | 0 (0.0%) | 1 (5.0%) | p = 0.139 | 0 (0.0%) | 0 (0.0%) | N/A |
| Acute liver failure | 3 (1.7%) | 0 (0%) | 3 (2.6%) | p = 0. 196 | 0 (0.0%) | 0 (0.0%) | N/A | 0 (0.0%) | 0 (0.0%) | N/A |
| Primary sclerosing cholangitis or primary biliary cirrhosis | 15 (8.4%) | 0 (0%) | 15 (13%) | p = 0.003 | 0 (0.0%) | 0 (0.0%) | N/A | 0 (0.0%) | 0 (0.0%) | N/A |
| Others (n, %) | 20 (11.2%) | 2 (3.2%) | 18 (15.7%) | p = 0.012 | 0 (0.0%) | 2 (10.0%) | p = 0.035 | 0 (0.0%) | 0 (0.0%) | N/A |
| Medical comorbidities | ||||||||||
| Diabetes mellitus | 45 (25.3%) | 15 (23.8%) | 30 (26.1%) | p = 0.738 | 11 (25.6) | 4 (20.0%) | p = 0.628 | 4 (22.2%) | 7 (28.0%) | p = 0.910 |
| Prior abdominal surgery | 88 (49.4%) | 39 (61.9%) | 49 (42.6%) | p = 0.041 | 26 (60.5%) | 13 (65.0%) | N/A | 9 (50.0%) | 17 (68.0%) | p = 0.365 |
| Hypertension | 64 (36%) | 22 (34.9%) | 42 (36.%) | p = 0.831 | 13 (30.2%) | 9 (45%) | p = 0.252 | 5 (27.8%) | 8 (32.0%) | p = 0.642 |
| Coronary artery disease | 12 (6.7%) | 5 (7.9%) | 7 (6.1%) | P = 0.638 | 4 (9.3%) | 1 (5.0%) | P = 0.556 | 3 (16.7%) | 3 (12.0%) | p = 0.686 |
| End-stage renal disease | 8 (4.5%) | 2 (3.2%) | 6 (5.2%) | p = 0.529 | 0 (0.0%) | 2 (10.0%) | p = 0.035 | 0 (0.0%) | 0 (0.0%) | p = 0.263 |
| Atrial fibrillation | 4 (2.2%) | 0 (0.0%) | 4 (3.5%) | p = 0.134 | 0 (0.0%) | 0 (0.0%) | N/A | 0 (0.0%) | 0 (0.0%) | N/A |
| COPD | 8 (4.5%) | 4 (6.3%) | 4 (3.5%) | p = 0.377 | 2 (4.7%) | 2 (10.0%) | p = 0.418 | 1 (5.6%) | 1 (4.0%) | p = 0.969 |
| History of arrhythmia (not A. Fib.) | 2 (1.1%) | 1 (1.6%) | 1 (0.9%) | p = 0.664 | 1 (2.3%) | 0 (0.0%) | p = 0.492 | 0 (0.0%) | 1 (4.0%) | p = 0.326 |
| Pulmonary hypertension | 6 (3.4%) | 2 (3.2%) | 4 (3.5%) | p = 0.915 | 2 (4.7%) | 0 (0.0%) | p = 0.327 | 0 (0.0%) | 2 (8.0%) | p = 0.310 |
| Esophageal varices | 53 (29.8%) | 19 (30.2%) | 34 (29.6%) | p = 0.934 | 14 (32.6%) | 5 (25.0%) | p = 0.543 | 6 (33.3%) | 8 (32.0%) | p = 0.898 |