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. 2016 Jun 13;7:203. doi: 10.3389/fimmu.2016.00203

Figure 2.

Figure 2

A schematic representation of the role of cross-reactive T cells directed against B180/B177 and R465 in regulation of AA. The T cells potentially reactive against B180/B177 of Bhsp65 (pathogenic epitope) and R465 of Rhsp65 (regulatory epitope) comprised a cross-reactive T cell subset besides the corresponding epitope-specific subset. The priming and expansion of these cross-reactive T cells by immunization of Lewis rats either with peptide (B180/B177 or with R465) in adjuvant would induce protection against subsequent AA (“vaccination”). However, injection of Mtb, which contains Bhsp65, instead activates predominantly the B180/B177-specific pathogenic repertoire, resulting in the induction of AA. Furthermore, this pathogenic repertoire may be inactivated, or immune-deviated, by soluble antigen (B180/B177) administered i.p. or nasally, leading to protection against AA. This schematic figure is based on our results published elsewhere (3, 11, 27, 30).