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Schematic model of ubiquitin and ubiquitin-like modifications in the DNA damage tolerance pathway. (A) Monoubiquitylation of PCNA leading to TLS. (B) Polyubiquitylation of PCNA leading to template switch. (C) ISGylation of PCNA and recovery from TLS. (D) SUMOylation of PCNA during unperturbed S phase and inhibition of Homologous Recombination. Dotted lines indicate interactions between regulators of the DDT and modified/unmodified PCNA.
