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. 2016 Jun 13;10:158. doi: 10.3389/fncel.2016.00158

Figure 2.

Figure 2

Effects of SI on GABAergic tonic currents in dentate gyrus (DG) granule cells: reversal by progesterone treatment. (A) Representative traces of GABAergic currents in the whole-cell voltage-clamp mode (holding potential, −65 mV) from DG granule cells present in slices obtained from mice of the different experimental groups. After a baseline of 3 min, bath perfusion of THIP (3 μM) induced an increase in holding current variance and a negative shift in the holding current. All GABAergic currents were blocked by 20 μM bicuculline (Bic). On the right, the current distribution graphs relative to each of the three different conditions (baseline, THIP and Bic) are shown. (B,C) Bar graphs summarizing the changes in holding current (B) and holding current variance (C). Data are presented as Mean ± SEM [n, 15 (GH), 26 (SI), 7 (GH+Prog), 7 (SI+Prog)] . *p < 0.05, ***p < 0.001 vs. GH (one-way ANOVA, and Bonferroni’s post hoc test).